text
stringlengths 528
2.32k
|
|---|
file_name=biomedica_00620688.jpg caption=In order to depict those processes orchestrating possible hippocampal structural and/or functional alterations in response to FST in the two novelty-seeking phenotypes, an additional set of selection criteria was applied, depicting statistically significant GO categories selected by one or more of the following keywords: neuro-, synaptic, stress, plasticity, cell death, cytoskeleton, migration, and adhesion (Figure ="fig" "1479-7364-8-4-3">3 ). This approach unveiled even greater differences between the molecular response of HR and LR rats to FST exposure. Notably, ‘synaptic transmission’ (21 genes), ‘cell migration’ (15 genes), ‘cell-cell adhesion’ (10 genes), ‘neurotransmitter transport’ (8 genes), and ‘neuroblast proliferation’ (4 genes) are among the GO BPs found to be represented only in the LR group, while ‘regulation of cell death’ (11 HR versus 21 LR genes), ‘cellular response to stress’ (11 HR versus 20 LR genes), and ‘actin cytoskeleton organization’ (5 HR versus 11 LR genes) source=biomedica enhanced_caption=O: In order to depict those processes orchestrating possible hippocampal structural and/or functional alterations in response to FST in the two novelty-seeking phenotypes, an additional set of selection criteria was applied, depicting statistically significant GO categories selected by one or more of the following keywords: neuro-, synaptic, stress, plasticity, cell death, cytoskeleton, migration, and adhesion (Figure ="fig" "1479-7364-8-4-3">3 ). This approach unveiled even greater differences between the molecular response of HR and LR rats to FST exposure. Notably, ‘synaptic transmission’ (21 genes), ‘cell migration’ (15 genes), ‘cell-cell adhesion’ (10 genes), ‘neurotransmitter transport’ (8 genes), and ‘neuroblast proliferation’ (4 genes) are among the GO BPs found to be represented only in the LR group, while ‘regulation of cell death’ (11 HR versus 21 LR genes), ‘cellular response to stress’ (11 HR versus 20 LR genes), and ‘actin cytoskeleton organization’ (5 HR versus 11 LR gen think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=48yo Middle Eastern male
|
file_name=biomedica_00383434.jpg caption=Visualization of Masson’s trichrome stain show collagen and muscle fibers. At eight weeks, some patch material still remains and is covered by collagen. Over the course of 24 weeks, the cardiac patch gradually degraded and could not be detected ( ="fig" "pone.0234087.g005">Fig 5A ). We assessed PGA fiber degradation and collagen formation using polarized light microscopy with Picro-Sirius Red (PSR) stained histological sections from 1, 2, 6 and 9 months after implantation. Under polarized light, the PGA fibers are birefringent and can be visualized. The PGA fibers can be seen as highly organized bundles within the scaffold at 1M after implantation, but by 2M the fibers had fragmented and nearly degraded. No fragments of the PGA fibers were visible at 6 months after implantation (). We assessed PGA fiber degradation and collagen formation using polarized light microscopy with Picro-Sirius Red (PSR) stained histological sections from 1, 2, 6 and 9 months after implantation. Under polariz source=biomedica enhanced_caption=O: Visualization of Masson’s trichrome stain show collagen and muscle fibers. At eight weeks, some patch material still remains and is covered by collagen. Over the course of 24 weeks, the cardiac patch gradually degraded and could not be detected ( ="fig" "pone.0234087.g005">Fig 5A ). We assessed PGA fiber degradation and collagen formation using polarized light microscopy with Picro-Sirius Red (PSR) stained histological sections from 1, 2, 6 and 9 months after implantation. Under polarized light, the PGA fibers are birefringent and can be visualized. The PGA fibers can be seen as highly organized bundles within the scaffold at 1M after implantation, but by 2M the fibers had fragmented and nearly degraded. No fragments of the PGA fibers were visible at 6 months after implantation (). We assessed PGA fiber degradation and collagen formation using polarized light microscopy with Picro-Sirius Red (PSR) stained histological sections from 1, 2, 6 and 9 months after implantation. Under pola think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=52yo Indigenous male
|
file_name=biomedica_00193164.jpg caption=In order to select the most important core genes from the above 15 genes, we used the String database to construct protein interaction networks and used Cytoscape software to present the results. ( "fonc-14-1351736-g006" ="fig"> <bold>Figure 6A</bold> ). Simultaneously, we used the Cytoscape package “CytoHubba” to screen five hub genes in the center of the interaction network, including CXCL8, CXCL10, CX3CR1, FCGR3B, and SELL (Figure 6A ). Simultaneously, we used the Cytoscape package “CytoHubba” to screen five hub genes in the center of the interaction network, including CXCL8, CXCL10, CX3CR1, FCGR3B, and SELL ( "fonc-14-1351736-g006" ="fig"> <bold>Figure 6B</bold> ). In addition, correlations between these five hub genes are shown. These five genes are the core of the protein interaction network; along with their expression varying in tumor cells, they also interact with most other differentially expressed genes.Figure 6B ). In addition, correlations between these five hub genes are source=biomedica enhanced_caption=O: In order to select the most important core genes from the above 15 genes, we used the String database to construct protein interaction networks and used Cytoscape software to present the results. ( "fonc-14-1351736-g006" ="fig"> <bold>Figure 6A</bold> ). Simultaneously, we used the Cytoscape package “CytoHubba” to screen five hub genes in the center of the interaction network, including CXCL8, CXCL10, CX3CR1, FCGR3B, and SELL (Figure 6A ). Simultaneously, we used the Cytoscape package “CytoHubba” to screen five hub genes in the center of the interaction network, including CXCL8, CXCL10, CX3CR1, FCGR3B, and SELL ( "fonc-14-1351736-g006" ="fig"> <bold>Figure 6B</bold> ). In addition, correlations between these five hub genes are shown. These five genes are the core of the protein interaction network; along with their expression varying in tumor cells, they also interact with most other differentially expressed genes.Figure 6B ). In addition, correlations between these five hub genes a think=<think>Visual findings present in image → Clinical correlation needed → ICD D49.9 assigned → Moderate uncertainty due to limited context</think> icd_code=D49.9 uncertainty=medium modality=multi-modal demographic=71yo Asian male
|
file_name=pmcvqa_00096417.jpg caption=Clinical Question: What does the green signal in panel AI indicate about complementing GFP? Answer: There is no green signal. source=pmcvqa enhanced_caption=O: Clinical Question: What does the green signal in panel AI indicate about complementing GFP? Answer: There is no green signal. A: Clinical findings require correlation. P: Further evaluation recommended. think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=radiology demographic=58yo White female
|
file_name=biomedica_00305396.jpg caption=TCMSP and TCMID databases were used to search for the chemical composition the eight herbs that constitute WJR. In total, WJR includes 493 chemicals. Based on the OB ≥30%, DL ≥0.18, and HL ≥4 screen criteria, we obtained 91 potential active compounds from WJR, of which 16 were from Astragali Preparata, 5 were from Atractylodes, 5 were from Sparganii Rhizoma, 3 were from Rhizoma Curcumae, 3 were from Agrimonia pilosa, 10 were from Coptidis Rhizoma, 42 were from Sophorae Flavescentis Radix, and 4 were from Coicis Semen ( Table S1 ). Corresponding relationships between therapeutic targets and active compounds, deleting duplicate targets, 81 active compounds, and 236 potential therapeutic targets were obtained ( Table S2 ). We next identified CRC-related targets from GeneCards, OMIM, and TTD databases. Based on the median values for Score, we obtained 1116 CRC-related targets ( Table S2 ). After intersecting the 236 WJR-related targets with 1116 CRC-related targets, 120 mutual targets were source=biomedica enhanced_caption=O: TCMSP and TCMID databases were used to search for the chemical composition the eight herbs that constitute WJR. In total, WJR includes 493 chemicals. Based on the OB ≥30%, DL ≥0.18, and HL ≥4 screen criteria, we obtained 91 potential active compounds from WJR, of which 16 were from Astragali Preparata, 5 were from Atractylodes, 5 were from Sparganii Rhizoma, 3 were from Rhizoma Curcumae, 3 were from Agrimonia pilosa, 10 were from Coptidis Rhizoma, 42 were from Sophorae Flavescentis Radix, and 4 were from Coicis Semen ( Table S1 ). Corresponding relationships between therapeutic targets and active compounds, deleting duplicate targets, 81 active compounds, and 236 potential therapeutic targets were obtained ( Table S2 ). We next identified CRC-related targets from GeneCards, OMIM, and TTD databases. Based on the median values for Score, we obtained 1116 CRC-related targets ( Table S2 ). After intersecting the 236 WJR-related targets with 1116 CRC-related targets, 120 mutual targets w think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=67yo Asian female
|
file_name=biomedica_00185645.jpg caption=The normalized PL spectra of films based on PXZ-CMO doped in (A) MCP and (B) DPEPO with different doping concentrations. source=biomedica enhanced_caption=O: The normalized PL spectra of films based on PXZ-CMO doped in (A) MCP and (B) DPEPO with different doping concentrations. A: Clinical findings require correlation. P: Further evaluation recommended. think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=36yo Indigenous female
|
file_name=biomedica_00548392.jpg caption=The first suspected cases of feline sporotrichosis emerged in March 2011 in the region of Itaquera, an urban area with a high population density. Cases are ongoing in the most neglected areas, which have limited access to basic sanitation and public health services (Figure "12917_2014_269_Fig1_HTML" ="fig">1 ). One hundred sixty-three out of 279 clinical samples from cats (58%) and 1 out of 11 samples from dogs (8%) were positive for several ). One hundred sixty-three out of 279 clinical samples from cats (58%) and 1 out of 11 samples from dogs (8%) were positive for several Sporothrix spp. in the city of São Paulo. Figure "12917_2014_269_Fig2_HTML" ="fig">2 shows the clinical aspects of feline sporotrichosis. In the metropolitan area of São Paulo, in the cities of Diadema and Guarulhos, 10 (100%) and 17 of 40 (43%) feline clinical samples were positive for shows the clinical aspects of feline sporotrichosis. In the metropolitan area of São Paulo, in the cities of Diadema and Guarulhos source=biomedica enhanced_caption=O: The first suspected cases of feline sporotrichosis emerged in March 2011 in the region of Itaquera, an urban area with a high population density. Cases are ongoing in the most neglected areas, which have limited access to basic sanitation and public health services (Figure "12917_2014_269_Fig1_HTML" ="fig">1 ). One hundred sixty-three out of 279 clinical samples from cats (58%) and 1 out of 11 samples from dogs (8%) were positive for several ). One hundred sixty-three out of 279 clinical samples from cats (58%) and 1 out of 11 samples from dogs (8%) were positive for several Sporothrix spp. in the city of São Paulo. Figure "12917_2014_269_Fig2_HTML" ="fig">2 shows the clinical aspects of feline sporotrichosis. In the metropolitan area of São Paulo, in the cities of Diadema and Guarulhos, 10 (100%) and 17 of 40 (43%) feline clinical samples were positive for shows the clinical aspects of feline sporotrichosis. In the metropolitan area of São Paulo, in the cities of Diadema and Guarul think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=32yo Hispanic female
|
file_name=biomedica_00678947.jpg caption=The loss of TH-positive neurons in the SN and the subsequent reduction in striatal TH expression are characteristic pathogenic processes in PD. Therefore, we assessed the number of TH +ve dopaminergic neurons in the SN, as well as their expression in the striatum. ROT injections into the rats resulted in the loss of TH-positive neurons (F 3, 20 = 35.100 p < 0.000), represented by a 50% decrease in the intensity of TH +ve striatal fibers ( "molecules-28-00685-g003" ="fig">Figure 3 ). Interestingly, myrcene treatment in rats injected with ROT prevented damage to dopaminergic neurons and increased TH (F 3, 20 = 11.223 ). Interestingly, myrcene treatment in rats injected with ROT prevented damage to dopaminergic neurons and increased TH (F 3, 20 = 11.223 p < 0.000) expression in striatal fibers, as demonstrated by immunohistochemical analysis. TH is a rate-limiting enzyme that catalyzes the formation of L-DOPA during dopamine (DA) biosynthesis. TH deficiency in the striatum is an important source=biomedica enhanced_caption=O: The loss of TH-positive neurons in the SN and the subsequent reduction in striatal TH expression are characteristic pathogenic processes in PD. Therefore, we assessed the number of TH +ve dopaminergic neurons in the SN, as well as their expression in the striatum. ROT injections into the rats resulted in the loss of TH-positive neurons (F 3, 20 = 35.100 p < 0.000), represented by a 50% decrease in the intensity of TH +ve striatal fibers ( "molecules-28-00685-g003" ="fig">Figure 3 ). Interestingly, myrcene treatment in rats injected with ROT prevented damage to dopaminergic neurons and increased TH (F 3, 20 = 11.223 ). Interestingly, myrcene treatment in rats injected with ROT prevented damage to dopaminergic neurons and increased TH (F 3, 20 = 11.223 p < 0.000) expression in striatal fibers, as demonstrated by immunohistochemical analysis. TH is a rate-limiting enzyme that catalyzes the formation of L-DOPA during dopamine (DA) biosynthesis. TH deficiency in the striatum is an import think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=45yo Black male
|
file_name=biomedica_00218460.jpg caption=More recently, Mieloszyk et al. presented an FBG-sensor-based SHM system for the monitoring of the technical condition of a 3 kW organic Rankine cycle (ORC) microturbine [118]. Sousa et al. [119] proposed an FBG-based sensing system to detect the initial stages of corrosion and to monitor the thickness loss of a 1020 carbon steel metal plate subjected to controlled corrosion using a NaCl solution. Specifically, they used a 0.1 M NaCl solution to induce corrosion in a region “h” with an area of 40.715 cm2 and used nine FBGs. The locations of each sensor and the “h” region are as shown in "sensors-23-04334-g012" ="fig">Figure 12 . In addition, Ho et al. [. In addition, Ho et al. [120] presented an SHM system based on FBG sensors which provides accurate time–deformation relations and frequency spectrum results. Moreover, they used the system for the SHM of a linear robot (LR). They used six FBGs to monitor the mechanical vibration and thermal expansion of the LR. The above FBG-sensor-base source=biomedica enhanced_caption=O: More recently, Mieloszyk et al. presented an FBG-sensor-based SHM system for the monitoring of the technical condition of a 3 kW organic Rankine cycle (ORC) microturbine [118]. Sousa et al. [119] proposed an FBG-based sensing system to detect the initial stages of corrosion and to monitor the thickness loss of a 1020 carbon steel metal plate subjected to controlled corrosion using a NaCl solution. Specifically, they used a 0.1 M NaCl solution to induce corrosion in a region “h” with an area of 40.715 cm2 and used nine FBGs. The locations of each sensor and the “h” region are as shown in "sensors-23-04334-g012" ="fig">Figure 12 . In addition, Ho et al. [. In addition, Ho et al. [120] presented an SHM system based on FBG sensors which provides accurate time–deformation relations and frequency spectrum results. Moreover, they used the system for the SHM of a linear robot (LR). They used six FBGs to monitor the mechanical vibration and thermal expansion of the LR. The above FBG-sensor-b think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=52yo Indigenous male
|
file_name=biomedica_00292960.jpg caption=Biofilms of PAO1-L were also tested for the impact of 6f on the potentiation of tobramycin activity (method 2). "jm3c00973_0007" ="fig">Figure "fig7" ="fig">7 shows that "jm3c00973_0007" ="fig">7 shows that 6f did not impact on the viability of preformed biofilms on its own, but when combined with tobramycin, it enhanced the killing at both 2 and 6 h of incubation with no live cells present at the later time point. source=biomedica enhanced_caption=O: Biofilms of PAO1-L were also tested for the impact of 6f on the potentiation of tobramycin activity (method 2). "jm3c00973_0007" ="fig">Figure "fig7" ="fig">7 shows that "jm3c00973_0007" ="fig">7 shows that 6f did not impact on the viability of preformed biofilms on its own, but when combined with tobramycin, it enhanced the killing at both 2 and 6 h of incubation with no live cells present at the later time point. A: Clinical findings require correlation. P: Further evaluation recommended. think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=39yo Middle Eastern female
|
file_name=biomedica_00773966.jpg caption=A 3D graph illustrating the predicted and calculated anti-protozoal activity of chlorinated steroids, specifically compounds 148, 149, and 150. The graph provides insights into the relationship between the activity of these compounds and their potential efficacy in inhibiting protozoan parasites. Anti-protozoal activity refers to the ability of a compound to inhibit the growth or survival of protozoan parasites, which are single-celled organisms that can cause various infectious diseases in humans and animals. Protozoan parasites can cause diseases such as malaria, leishmaniasis, trypanosomiasis, and toxoplasmosis, among others. The predicted and calculated activity values depicted on the graph represent the potency or effectiveness of the chlorinated steroids in terms of their anti-protozoal properties. With a confidence level of over 95%, the graph indicates a high degree of certainty in the accuracy of the predicted and calculated activity values. The exploration of chlorinated ster source=biomedica enhanced_caption=O: A 3D graph illustrating the predicted and calculated anti-protozoal activity of chlorinated steroids, specifically compounds 148, 149, and 150. The graph provides insights into the relationship between the activity of these compounds and their potential efficacy in inhibiting protozoan parasites. Anti-protozoal activity refers to the ability of a compound to inhibit the growth or survival of protozoan parasites, which are single-celled organisms that can cause various infectious diseases in humans and animals. Protozoan parasites can cause diseases such as malaria, leishmaniasis, trypanosomiasis, and toxoplasmosis, among others. The predicted and calculated activity values depicted on the graph represent the potency or effectiveness of the chlorinated steroids in terms of their anti-protozoal properties. With a confidence level of over 95%, the graph indicates a high degree of certainty in the accuracy of the predicted and calculated activity values. The exploration of chlorinated s think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=71yo Asian male
|
file_name=biomedica_00130093.jpg caption=Over three months, 655 nests that contained live insects at 53 nesting sites were sampled and 23 species of insects were found to be associated with the use of mud nests. Within the sampling range, the species accumulation curve almost reached the asymptote ( "insects-13-01136-g004" ="fig">Figure 4 ), implying that the number of nests collected may explain all possible insect diversity. This suggests that within the sampling period, we have closely recorded the greatest richness of insects that are associated with the use of the ), implying that the number of nests collected may explain all possible insect diversity. This suggests that within the sampling period, we have closely recorded the greatest richness of insects that are associated with the use of the Sceliphron mud nest. source=biomedica enhanced_caption=O: Over three months, 655 nests that contained live insects at 53 nesting sites were sampled and 23 species of insects were found to be associated with the use of mud nests. Within the sampling range, the species accumulation curve almost reached the asymptote ( "insects-13-01136-g004" ="fig">Figure 4 ), implying that the number of nests collected may explain all possible insect diversity. This suggests that within the sampling period, we have closely recorded the greatest richness of insects that are associated with the use of the ), implying that the number of nests collected may explain all possible insect diversity. This suggests that within the sampling period, we have closely recorded the greatest richness of insects that are associated with the use of the Sceliphron mud nest. A: Clinical findings require correlation. P: Further evaluation recommended. think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=28yo South Asian female
|
file_name=biomedica_00559289.jpg caption=Measurementof DNA methylation by bisulfite sequencing of gene body CpG islands from all known hematopoietic genes.(a) Schematic diagram showing the method used to collect blood from 5–7 dpf embryos for bisulfite analysis. (b–k) Bisulfite sequencing of blood cell genomic DNA from 5–7 dpf control (top) and dnmt3bb.1 (bottom) morpholino-injected animals. The results are shown for ten different sequences identified in a genome-wide screen for gene body CpG islands methylated in blood cells: cmyb (b), runx1 (c), CCAT/enhancer binding protein 1-Exon 1 (d), Kruppel like factor 4-Exon 3 (e), Nuclear receptor co-repressor-2-Exon 37 (f), RALBP1 associated domain containing 2-Exon 2 (g), short stature homeobox-Exon 5 (h), solute carrier family 12-Exon 1 (i) and solute carrier family 8–5’ UTR (j), lamin a-Exon 7 (k). Open circles represent unmethylated and filled circles represent methylated cytosine residues from CpG dinucleotides.DOI: http://dx.doi.org/10.7554/eLife.11813.012 source=biomedica enhanced_caption=O: Measurementof DNA methylation by bisulfite sequencing of gene body CpG islands from all known hematopoietic genes.(a) Schematic diagram showing the method used to collect blood from 5–7 dpf embryos for bisulfite analysis. (b–k) Bisulfite sequencing of blood cell genomic DNA from 5–7 dpf control (top) and dnmt3bb.1 (bottom) morpholino-injected animals. The results are shown for ten different sequences identified in a genome-wide screen for gene body CpG islands methylated in blood cells: cmyb (b), runx1 (c), CCAT/enhancer binding protein 1-Exon 1 (d), Kruppel like factor 4-Exon 3 (e), Nuclear receptor co-repressor-2-Exon 37 (f), RALBP1 associated domain containing 2-Exon 2 (g), short stature homeobox-Exon 5 (h), solute carrier family 12-Exon 1 (i) and solute carrier family 8–5’ UTR (j), lamin a-Exon 7 (k). Open circles represent unmethylated and filled circles represent methylated cytosine residues from CpG dinucleotides.DOI: http://dx.doi.org/10.7554/eLife.11813.012 A: Clinical find think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=64yo Pacific Islander male
|
file_name=biomedica_00502183.jpg caption=The in vitro release of Rho123 from control solutions and FT mixed micelles under sink condition was investigated by dialysis method with PBS (pH 7.4) as release medium. As shown in Fig. "41598_2017_3123_Fig3_HTML" ="fig">3 , almost all Rho123 was released from the methanol solution at the 4 h. During the same time period, only about 55% of Rho123 was released from FT/Rho123. After 24 h, 30–40% of the initially incorporated drug still existed in the micelles. The results indicated that the micelles showed sustained release as compared with free drug., almost all Rho123 was released from the methanol solution at the 4 h. During the same time period, only about 55% of Rho123 was released from FT/Rho123. After 24 h, 30–40% of the initially incorporated drug still existed in the micelles. The results indicated that the micelles showed sustained release as compared with free drug.Figure 3 In vitro release of Rho 123-loaded FT mixed micelles. Free Rho123 dissolved in methanol was used as con source=biomedica enhanced_caption=O: The in vitro release of Rho123 from control solutions and FT mixed micelles under sink condition was investigated by dialysis method with PBS (pH 7.4) as release medium. As shown in Fig. "41598_2017_3123_Fig3_HTML" ="fig">3 , almost all Rho123 was released from the methanol solution at the 4 h. During the same time period, only about 55% of Rho123 was released from FT/Rho123. After 24 h, 30–40% of the initially incorporated drug still existed in the micelles. The results indicated that the micelles showed sustained release as compared with free drug., almost all Rho123 was released from the methanol solution at the 4 h. During the same time period, only about 55% of Rho123 was released from FT/Rho123. After 24 h, 30–40% of the initially incorporated drug still existed in the micelles. The results indicated that the micelles showed sustained release as compared with free drug.Figure 3 In vitro release of Rho 123-loaded FT mixed micelles. Free Rho123 dissolved in methanol was used as think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=25yo White male
|
file_name=biomedica_00337901.jpg caption=The coagulation results and the results obtained for other laboratory parameters of interest are presented in Table 1, Table 2 and "animals-13-00164-g003" ="fig">Figure 3 . No platelet counts below the reference value were observed in any of the dogs at any time [platelets < 128 × 10. No platelet counts below the reference value were observed in any of the dogs at any time [platelets < 128 × 109/L (<128 × 103 cells/µL)]. Two dogs had a PPT below the lower reference range at T0 (respectively 11 and 11.7 s). The fibrinogen concentration was below the reference range in one dog at T0 (132 mg/dL) and over the range in 2 dogs at T0 (675 mg/dL) and at T1 (579 mg/dL). One dog had proteinuria at T0 (UPC 1.93). source=biomedica enhanced_caption=O: The coagulation results and the results obtained for other laboratory parameters of interest are presented in Table 1, Table 2 and "animals-13-00164-g003" ="fig">Figure 3 . No platelet counts below the reference value were observed in any of the dogs at any time [platelets < 128 × 10. No platelet counts below the reference value were observed in any of the dogs at any time [platelets < 128 × 109/L (<128 × 103 cells/µL)]. Two dogs had a PPT below the lower reference range at T0 (respectively 11 and 11.7 s). The fibrinogen concentration was below the reference range in one dog at T0 (132 mg/dL) and over the range in 2 dogs at T0 (675 mg/dL) and at T1 (579 mg/dL). One dog had proteinuria at T0 (UPC 1.93). A: Clinical findings require correlation. P: Further evaluation recommended. think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=42yo Black female
|
file_name=biomedica_00089630.jpg caption=In the 18th month since the end of chemotherapy, a routine MRI found that the perihepatic masses had increased in number and dimension. The investigation found intrahepatic, perihepatic, and subdiaphragmatic fat-containing lesions of a maximum of 2/1.5 cm ( "medicina-58-01715-g003" ="fig">Figure 3 C,D), a smaller mass of approximately 1.1/0.6 cm in the hepatorenal recess, and another of 0.4 cm in the gastrosplenic recess. Tumor markers AFP, b-HCG, and CA-125 were normal; therefore, the rare growing teratoma syndrome (GTS) was feared as a severe outcome [C,D), a smaller mass of approximately 1.1/0.6 cm in the hepatorenal recess, and another of 0.4 cm in the gastrosplenic recess. Tumor markers AFP, b-HCG, and CA-125 were normal; therefore, the rare growing teratoma syndrome (GTS) was feared as a severe outcome [21,22]. Five tumor masses were removed by exploratory laparotomy two weeks later, and the pathology exam found all the lesions to be lipomas. Our patient showed no signs of preexi source=biomedica enhanced_caption=O: In the 18th month since the end of chemotherapy, a routine MRI found that the perihepatic masses had increased in number and dimension. The investigation found intrahepatic, perihepatic, and subdiaphragmatic fat-containing lesions of a maximum of 2/1.5 cm ( "medicina-58-01715-g003" ="fig">Figure 3 C,D), a smaller mass of approximately 1.1/0.6 cm in the hepatorenal recess, and another of 0.4 cm in the gastrosplenic recess. Tumor markers AFP, b-HCG, and CA-125 were normal; therefore, the rare growing teratoma syndrome (GTS) was feared as a severe outcome [C,D), a smaller mass of approximately 1.1/0.6 cm in the hepatorenal recess, and another of 0.4 cm in the gastrosplenic recess. Tumor markers AFP, b-HCG, and CA-125 were normal; therefore, the rare growing teratoma syndrome (GTS) was feared as a severe outcome [21,22]. Five tumor masses were removed by exploratory laparotomy two weeks later, and the pathology exam found all the lesions to be lipomas. Our patient showed no signs of pre think=<think>Visual findings present in image → Clinical correlation needed → ICD D49.9 assigned → Moderate uncertainty due to limited context</think> icd_code=D49.9 uncertainty=medium modality=multi-modal demographic=32yo Hispanic female
|
file_name=biomedica_00542756.jpg caption=In the absence of driving-Y chromosomes, we expect considerable variation in the dynamics of local mosquito populations, due to differences in the distribution of permanent groundwater, rainfall, and the connectedness of local populations. Further variation may stem from the variable application of existing vector control measures, in particular bed nets. This heterogeneity influences the spread of the driving-Y chromosome with most rapid advances occurring in densely populated parts of the landscape where dispersal between neighbouring settlements is frequent (Fig. "12915_2019_645_Fig2_HTML" ="fig">2 ). With our default assumptions, all but the most isolated settlements receive driving-Y chromosomes within 4 years of releases (98.7% of settlements; 98.6–99.1%), though we note that this result is sensitive to the parameterisation of dispersal, something we return to below. ). With our default assumptions, all but the most isolated settlements receive driving-Y chromosomes within 4 year source=biomedica enhanced_caption=O: In the absence of driving-Y chromosomes, we expect considerable variation in the dynamics of local mosquito populations, due to differences in the distribution of permanent groundwater, rainfall, and the connectedness of local populations. Further variation may stem from the variable application of existing vector control measures, in particular bed nets. This heterogeneity influences the spread of the driving-Y chromosome with most rapid advances occurring in densely populated parts of the landscape where dispersal between neighbouring settlements is frequent (Fig. "12915_2019_645_Fig2_HTML" ="fig">2 ). With our default assumptions, all but the most isolated settlements receive driving-Y chromosomes within 4 years of releases (98.7% of settlements; 98.6–99.1%), though we note that this result is sensitive to the parameterisation of dispersal, something we return to below. ). With our default assumptions, all but the most isolated settlements receive driving-Y chromosomes within 4 y think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=48yo Middle Eastern male
|
file_name=biomedica_00661691.jpg caption=Diffraction wavelength of GCCA-lens shifted responsive to glucose concentration changing. (a) Visible color shift of GCCA-lens according to glucose concentration change; (b) The diffraction response at low glucose concentration (insert is the photograph of the GCCA-lens sample). source=biomedica enhanced_caption=O: Diffraction wavelength of GCCA-lens shifted responsive to glucose concentration changing. (a) Visible color shift of GCCA-lens according to glucose concentration change; (b) The diffraction response at low glucose concentration (insert is the photograph of the GCCA-lens sample). A: Clinical findings require correlation. P: Further evaluation recommended. think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=25yo White male
|
file_name=biomedica_00635743.jpg caption=The mean values of fasting plasma glucose increased with age in OLETF rats, whereas no changes were observed in LETO rats during the study period ( ="fig" "pone.0160177.g004">Fig 4 ).). source=biomedica enhanced_caption=O: The mean values of fasting plasma glucose increased with age in OLETF rats, whereas no changes were observed in LETO rats during the study period ( ="fig" "pone.0160177.g004">Fig 4 ).). A: Clinical findings require correlation. P: Further evaluation recommended. think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=32yo Hispanic female
|
file_name=biomedica_00271027.jpg caption=To investigate whether the high mortality rate observed in mutant mice was consistent with organ injury, we examined the extent of histological liver damage in both strains at the onset of heatstroke, and during the recovery period. The liver, was selected because it is a vulnerable site to heat injury [28], [29]. As expected, there were no changes observed in the sham-heated group for both strains ( ="fig" "pone.0044100.g003">Fig. 3A & E ). In contrast, heat stressed animals displayed widespread damage that varied between the two strains. Extensive damage was observed in mutant mice following heat stress (). In contrast, heat stressed animals displayed widespread damage that varied between the two strains. Extensive damage was observed in mutant mice following heat stress ( ="fig" "pone.0044100.g003">Fig. 3B–D ). The changes consisted of focal hepatocytes necrosis associated with marked inflammatory cells infiltration at the onset of heatstroke (). The changes consisted of focal h source=biomedica enhanced_caption=O: To investigate whether the high mortality rate observed in mutant mice was consistent with organ injury, we examined the extent of histological liver damage in both strains at the onset of heatstroke, and during the recovery period. The liver, was selected because it is a vulnerable site to heat injury [28], [29]. As expected, there were no changes observed in the sham-heated group for both strains ( ="fig" "pone.0044100.g003">Fig. 3A & E ). In contrast, heat stressed animals displayed widespread damage that varied between the two strains. Extensive damage was observed in mutant mice following heat stress (). In contrast, heat stressed animals displayed widespread damage that varied between the two strains. Extensive damage was observed in mutant mice following heat stress ( ="fig" "pone.0044100.g003">Fig. 3B–D ). The changes consisted of focal hepatocytes necrosis associated with marked inflammatory cells infiltration at the onset of heatstroke (). The changes consisted of foca think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=36yo Indigenous female
|
file_name=biomedica_00118811.jpg caption=Since HIF‐1α plays an important role in maintaining intestinal homeostasis and glycolysis, 6 , 37 we further assessed mRNA expression of HIF‐1α and dynamic changes of glycolysis in neutrophils of ASUC patients treated with CsA. Surprisingly, we found that CsA markedly induced the mRNA expression of HIF‐1α in neutrophils on day 8 after CsA treatment in the Response group (Figure "CTM2-11-e334-g004" ="fig">4A ) but not in the Nonresponse group (Figure ) but not in the Nonresponse group (Figure "CTM2-11-e334-g004" ="fig">4B ). The assay of ECAR was performed and revealed that an enhancement of glycolysis was also observed in neutrophils under in vitro stimulation with CsA from the Response group but not from the Nonresponse group (Figure 4C). To investigate antibacterial ability of neutrophils under stimulation with CsA, we measured expression of antimicrobial peptides as well as ROS and MPO production, and found that the levels of antimicrobial peptides including S100A8 and S100A9 (Figur source=biomedica enhanced_caption=O: Since HIF‐1α plays an important role in maintaining intestinal homeostasis and glycolysis, 6 , 37 we further assessed mRNA expression of HIF‐1α and dynamic changes of glycolysis in neutrophils of ASUC patients treated with CsA. Surprisingly, we found that CsA markedly induced the mRNA expression of HIF‐1α in neutrophils on day 8 after CsA treatment in the Response group (Figure "CTM2-11-e334-g004" ="fig">4A ) but not in the Nonresponse group (Figure ) but not in the Nonresponse group (Figure "CTM2-11-e334-g004" ="fig">4B ). The assay of ECAR was performed and revealed that an enhancement of glycolysis was also observed in neutrophils under in vitro stimulation with CsA from the Response group but not from the Nonresponse group (Figure 4C). To investigate antibacterial ability of neutrophils under stimulation with CsA, we measured expression of antimicrobial peptides as well as ROS and MPO production, and found that the levels of antimicrobial peptides including S100A8 and S100A9 (Fi think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=64yo Pacific Islander male
|
file_name=biomedica_00579327.jpg caption=The preparation of straightaway grown CNP‒CP material with HNA is schematically interpreted in Figure "ADVS-9-2104877-g007" ="fig"> <bold>1</bold> . First and foremost, the current collector is one of the main requirements in the construction of energy storage systems. Until now, different conducting substrates like nickel foam/foil, copper foam/foil, titanium foil, stainless steel foil, graphite sheet, etc. have been employed as current collectors.1 . First and foremost, the current collector is one of the main requirements in the construction of energy storage systems. Until now, different conducting substrates like nickel foam/foil, copper foam/foil, titanium foil, stainless steel foil, graphite sheet, etc. have been employed as current collectors.[ 15 ] However, these substrates are not able to have a significant impact on the flexible energy storage systems due to their rigidness and nonflexible properties. In contrast, textile‐based substrates bestow shape resilience features, th source=biomedica enhanced_caption=O: The preparation of straightaway grown CNP‒CP material with HNA is schematically interpreted in Figure "ADVS-9-2104877-g007" ="fig"> <bold>1</bold> . First and foremost, the current collector is one of the main requirements in the construction of energy storage systems. Until now, different conducting substrates like nickel foam/foil, copper foam/foil, titanium foil, stainless steel foil, graphite sheet, etc. have been employed as current collectors.1 . First and foremost, the current collector is one of the main requirements in the construction of energy storage systems. Until now, different conducting substrates like nickel foam/foil, copper foam/foil, titanium foil, stainless steel foil, graphite sheet, etc. have been employed as current collectors.[ 15 ] However, these substrates are not able to have a significant impact on the flexible energy storage systems due to their rigidness and nonflexible properties. In contrast, textile‐based substrates bestow shape resilience features, think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=48yo Middle Eastern male
|
file_name=biomedica_00135007.jpg caption=Metabolomics is the comprehensive study of small molecules (50–1500 Da) and can measure effects of endogenous and exogenous phenomena which affect phenotype [1]. Considering the proximity to the biologic phenotype, metabolomics holds great potential in objectively measuring and understanding tissue pathophysiological processes, including the impact of multiple genetic, nutritional, and environmental factors. Due to the early pathological changes in metabolic profiles and the technical capabilities to analyse multiple features at once, metabolomics can facilitate in-depth investigations of VHD [24, 25, 26, 27, 28, 29]. Researchers need to decide a priori whether to use targeted or untargeted metabolomics approaches for their studies (Fig. "2153-8174-[DATE]-g3" ="fig">3 ).). source=biomedica enhanced_caption=O: Metabolomics is the comprehensive study of small molecules (50–1500 Da) and can measure effects of endogenous and exogenous phenomena which affect phenotype [1]. Considering the proximity to the biologic phenotype, metabolomics holds great potential in objectively measuring and understanding tissue pathophysiological processes, including the impact of multiple genetic, nutritional, and environmental factors. Due to the early pathological changes in metabolic profiles and the technical capabilities to analyse multiple features at once, metabolomics can facilitate in-depth investigations of VHD [24, 25, 26, 27, 28, 29]. Researchers need to decide a priori whether to use targeted or untargeted metabolomics approaches for their studies (Fig. "2153-8174-[DATE]-g3" ="fig">3 ).). A: Clinical findings require correlation. P: Further evaluation recommended. think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=67yo Asian female
|
file_name=biomedica_00040300.jpg caption=To facilitate the search, we used two curated TF binding profiles for human RFX available in the JASPAR (2018) database [47]: RFX2 (MA0600.1) and RFX5 (MA0510.1) (Table S4 in Additional file 3). As a control, we selected a 10-fold larger random set of TSS locations across the human genome. Our search effort revealed that X-box hits are typically located very close to RFX target genes TSS locations (Fig. "12864_2018_4564_Fig3_HTML" ="fig">3 , Table S5 in Additional file , Table S5 in Additional file 3). Based on search and find statistics the X-box positioning window can be further subdivided into a robust window of − 500 to + 500 bp and a permissive window of − 2300 to + 1400 bp. Using an independent search approach (the MEME suite FIMO software) [48] we confirmed these overall search and find parameters for human X-box motifs. Our analysis enhances the prediction power of future searches for functional X-box motifs, which relates to both upstream and downstream of TSS locations of can source=biomedica enhanced_caption=O: To facilitate the search, we used two curated TF binding profiles for human RFX available in the JASPAR (2018) database [47]: RFX2 (MA0600.1) and RFX5 (MA0510.1) (Table S4 in Additional file 3). As a control, we selected a 10-fold larger random set of TSS locations across the human genome. Our search effort revealed that X-box hits are typically located very close to RFX target genes TSS locations (Fig. "12864_2018_4564_Fig3_HTML" ="fig">3 , Table S5 in Additional file , Table S5 in Additional file 3). Based on search and find statistics the X-box positioning window can be further subdivided into a robust window of − 500 to + 500 bp and a permissive window of − 2300 to + 1400 bp. Using an independent search approach (the MEME suite FIMO software) [48] we confirmed these overall search and find parameters for human X-box motifs. Our analysis enhances the prediction power of future searches for functional X-box motifs, which relates to both upstream and downstream of TSS locations of think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=36yo Indigenous female
|
file_name=biomedica_00350276.jpg caption=The diagram in ="fig" "CGGR2012-818564.009">Figure 9 represents the idealized composite of three datasets, which illustrate both the simple (1-peak) and complex (2-peak) Janus model of life-course dynamics. The first (I) phase of growing and maturation, followed by the first dotted trajectory of decline, corresponds with the simple Janus model of development and aging (cf. represents the idealized composite of three datasets, which illustrate both the simple (1-peak) and complex (2-peak) Janus model of life-course dynamics. The first (I) phase of growing and maturation, followed by the first dotted trajectory of decline, corresponds with the simple Janus model of development and aging (cf. ="fig" "CGGR2012-818564.005">Figure 5 ). The complex, 2-peak Janus model might cover the first (I), second (II), and third (III) phases of the total life trajectory, that is, development (growth)—stationary phase—aging (decline), and could also be fitted to the last three phases (II, III, IV), depend source=biomedica enhanced_caption=O: The diagram in ="fig" "CGGR2012-818564.009">Figure 9 represents the idealized composite of three datasets, which illustrate both the simple (1-peak) and complex (2-peak) Janus model of life-course dynamics. The first (I) phase of growing and maturation, followed by the first dotted trajectory of decline, corresponds with the simple Janus model of development and aging (cf. represents the idealized composite of three datasets, which illustrate both the simple (1-peak) and complex (2-peak) Janus model of life-course dynamics. The first (I) phase of growing and maturation, followed by the first dotted trajectory of decline, corresponds with the simple Janus model of development and aging (cf. ="fig" "CGGR2012-818564.005">Figure 5 ). The complex, 2-peak Janus model might cover the first (I), second (II), and third (III) phases of the total life trajectory, that is, development (growth)—stationary phase—aging (decline), and could also be fitted to the last three phases (II, III, IV), dep think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=71yo Asian male
|
file_name=biomedica_00052374.jpg caption=Our systematic search identified a total of 2276 citations from inception to October 2023 ( "fpsyt-15-1356773-g001" ="fig"> <bold>Figure 1</bold> ). From these, 38 reports were assessed for full-text assessment, and 29 studies met the eligibility criteria for inclusion in this review. 9 records were excluded due to wrong intervention, and wrong study design. Kappa Interobserver agreement was determined to be good (k = 0.78), and disagreements were solved by consensus.Figure 1 ). From these, 38 reports were assessed for full-text assessment, and 29 studies met the eligibility criteria for inclusion in this review. 9 records were excluded due to wrong intervention, and wrong study design. Kappa Interobserver agreement was determined to be good (k = 0.78), and disagreements were solved by consensus. source=biomedica enhanced_caption=O: Our systematic search identified a total of 2276 citations from inception to October 2023 ( "fpsyt-15-1356773-g001" ="fig"> <bold>Figure 1</bold> ). From these, 38 reports were assessed for full-text assessment, and 29 studies met the eligibility criteria for inclusion in this review. 9 records were excluded due to wrong intervention, and wrong study design. Kappa Interobserver agreement was determined to be good (k = 0.78), and disagreements were solved by consensus.Figure 1 ). From these, 38 reports were assessed for full-text assessment, and 29 studies met the eligibility criteria for inclusion in this review. 9 records were excluded due to wrong intervention, and wrong study design. Kappa Interobserver agreement was determined to be good (k = 0.78), and disagreements were solved by consensus. A: Clinical findings require correlation. P: Further evaluation recommended. think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=67yo Asian female
|
file_name=biomedica_00489140.jpg caption=Subsequently, we aimed to visualize the localization of active translation during virus infection by puromycin incorporation into nascent polypeptides on immobilized ribosomes (ribopuromycylation) followed by fluorescence imaging using antibodies directed against puromycin (David et al., 2012). In non-infected L929 cells, ribopuromycylation resulted in an expected diffuse, mainly cytosolic, staining pattern interspersed with punctate structures indicative of translation localized to dedicated subcellular cytosolic locations ( ="fig" "elife-42037-fig6">Figure 6 ). In striking contrast, MHV-infected L929 cells displayed a pronounced enrichment of actively translating ribosomes near the viral RTC as indicated by the strong overlap between the viral replicase and the ribopuromycylation stain. Interestingly, active translation in vicinity of the RTC was strongest during the early phase of infection at 6 h.p.i., and was observed until 8 h.p.i., before gradually decreasing as the infection ad source=biomedica enhanced_caption=O: Subsequently, we aimed to visualize the localization of active translation during virus infection by puromycin incorporation into nascent polypeptides on immobilized ribosomes (ribopuromycylation) followed by fluorescence imaging using antibodies directed against puromycin (David et al., 2012). In non-infected L929 cells, ribopuromycylation resulted in an expected diffuse, mainly cytosolic, staining pattern interspersed with punctate structures indicative of translation localized to dedicated subcellular cytosolic locations ( ="fig" "elife-42037-fig6">Figure 6 ). In striking contrast, MHV-infected L929 cells displayed a pronounced enrichment of actively translating ribosomes near the viral RTC as indicated by the strong overlap between the viral replicase and the ribopuromycylation stain. Interestingly, active translation in vicinity of the RTC was strongest during the early phase of infection at 6 h.p.i., and was observed until 8 h.p.i., before gradually decreasing as the infection think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=55yo Hispanic male
|
file_name=pmcvqa_00036494.jpg caption=Clinical Question: What is the imaging feature for image e? Answer: Multiple mixed distributed pure GGO, GGO with consolidation, and interlobular septal thickening in bilateral lungs. source=pmcvqa enhanced_caption=O: Clinical Question: What is the imaging feature for image e? Answer: Multiple mixed distributed pure GGO, GGO with consolidation, and interlobular septal thickening in bilateral lungs. A: Clinical findings require correlation. P: Further evaluation recommended. think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=radiology demographic=71yo Asian male
|
file_name=biomedica_00521452.jpg caption=Thirty-one additional Sentinel-1A images with ascending orbit (Table 1) were processed using the multi-temporal InSAR technique to generate the ground deformation between 23 January 2015 and 17 February 2017 with the purpose of comparing with ALOS-derived deformation. After setting the spatial-temporal baselines ( ="fig" "sensors-19-04425-g0A1">Figure A1 in the in the Appendix A), the time series deformation was produced over the study area, as shown in ="fig" "sensors-19-04425-g0A2">Figure A2 in the in the Appendix A. Due to no overlapping time between these two datasets, the annual deformation velocity maps were compared to investigate the relationship, as shown in ="fig" "sensors-19-04425-g008">Figure 8 a,b; a,b; ="fig" "sensors-19-04425-g008">Figure 8 a shows the result from L-band ALOS-1 and a shows the result from L-band ALOS-1 and ="fig" "sensors-19-04425-g008">Figure 8 b shows the result from C-band Sentinel-1A. It was observed that there was clear difference in the distributio source=biomedica enhanced_caption=O: Thirty-one additional Sentinel-1A images with ascending orbit (Table 1) were processed using the multi-temporal InSAR technique to generate the ground deformation between 23 January 2015 and 17 February 2017 with the purpose of comparing with ALOS-derived deformation. After setting the spatial-temporal baselines ( ="fig" "sensors-19-04425-g0A1">Figure A1 in the in the Appendix A), the time series deformation was produced over the study area, as shown in ="fig" "sensors-19-04425-g0A2">Figure A2 in the in the Appendix A. Due to no overlapping time between these two datasets, the annual deformation velocity maps were compared to investigate the relationship, as shown in ="fig" "sensors-19-04425-g008">Figure 8 a,b; a,b; ="fig" "sensors-19-04425-g008">Figure 8 a shows the result from L-band ALOS-1 and a shows the result from L-band ALOS-1 and ="fig" "sensors-19-04425-g008">Figure 8 b shows the result from C-band Sentinel-1A. It was observed that there was clear difference in the distribu think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=32yo Hispanic female
|
file_name=biomedica_00426547.jpg caption=Now let us comment about the use of the term ‘weak law’. In one hand, the common value (for the most populated municipalities in recent times) appears as a kind of law of a phenomenon not yet measured up to now. This phenomenon concerns the involvement of the electorate, from a civic point of view. A kind of law, because it occurs very frequently, with strong regularities despite wide disparities across elections. As we have seen, it implies the existence of particular correlations between and . In other hand, this is clearly not a ‘hard’ or ‘strong’ law since noticeable deviations are observed. One cannot exclude that a ‘strong’ law exists, encapsulating more regularities for the most populated municipalities (e.g. by taking into account not only , and , but also parameters characterizing the political context, the number of valid votes for different choices, etc.). Such more global law might explain why appears in recent times and why this phenomenon is not observed for small municip source=biomedica enhanced_caption=O: Now let us comment about the use of the term ‘weak law’. In one hand, the common value (for the most populated municipalities in recent times) appears as a kind of law of a phenomenon not yet measured up to now. This phenomenon concerns the involvement of the electorate, from a civic point of view. A kind of law, because it occurs very frequently, with strong regularities despite wide disparities across elections. As we have seen, it implies the existence of particular correlations between and . In other hand, this is clearly not a ‘hard’ or ‘strong’ law since noticeable deviations are observed. One cannot exclude that a ‘strong’ law exists, encapsulating more regularities for the most populated municipalities (e.g. by taking into account not only , and , but also parameters characterizing the political context, the number of valid votes for different choices, etc.). Such more global law might explain why appears in recent times and why this phenomenon is not observed for small muni think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=55yo Hispanic male
|
file_name=biomedica_00423178.jpg caption=The radius of gyration (Rg) allows us to assess the changes in compactness of a ligand–protein complex. Finally, higher Rg reduces the compactness of the ligand–protein complex. During the MD simulation, Rg is used to determine if the complexes are stable, folded or unfolded. 3WQK-ASA has an average Rg value of around 2.05 nm (Fig. "13568_2023_1616_Fig3_HTML" ="fig">3 a). Furthermore, the Rg value of the Rifampin-rpoB complex was 2.4 nm, which is very similar to the reference molecule. (Fig. a). Furthermore, the Rg value of the Rifampin-rpoB complex was 2.4 nm, which is very similar to the reference molecule. (Fig. "13568_2023_1616_Fig3_HTML" ="fig">3 b).b).Fig. 3A plot for Radius of Gyration a 3WQK_ASA b rpoB_Rifampin source=biomedica enhanced_caption=O: The radius of gyration (Rg) allows us to assess the changes in compactness of a ligand–protein complex. Finally, higher Rg reduces the compactness of the ligand–protein complex. During the MD simulation, Rg is used to determine if the complexes are stable, folded or unfolded. 3WQK-ASA has an average Rg value of around 2.05 nm (Fig. "13568_2023_1616_Fig3_HTML" ="fig">3 a). Furthermore, the Rg value of the Rifampin-rpoB complex was 2.4 nm, which is very similar to the reference molecule. (Fig. a). Furthermore, the Rg value of the Rifampin-rpoB complex was 2.4 nm, which is very similar to the reference molecule. (Fig. "13568_2023_1616_Fig3_HTML" ="fig">3 b).b).Fig. 3A plot for Radius of Gyration a 3WQK_ASA b rpoB_Rifampin A: Clinical findings require correlation. P: Further evaluation recommended. think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=25yo White male
|
file_name=biomedica_00683634.jpg caption=The HUMSCs, obtained from the WJ of human umbilical cord with informed consents, had a typical spindle shape and resembled fibroblasts, consistent with the morphology reported by others [12, 27]. Although a specific antigen profile of HUMSCs has not been defined, for each isolation and culture, we verified by flow cytometry that the isolated cells were positive for the mesenchymal markers CD73, CD90 and CD105 (Figure ="fig" "oncotarget-07-51815-g001">1A ) and negative for typical hematopoietic antigens CD34, CD45 and CD19 (Figure ) and negative for typical hematopoietic antigens CD34, CD45 and CD19 (Figure ="fig" "oncotarget-07-51815-g001">1B ) as previously described [) as previously described [13]. Moreover, the HUMSCs were able to undergo adipogenesis (Figure ="fig" "oncotarget-07-51815-g001">1C ) and osteogenesis (Figure ) and osteogenesis (Figure ="fig" "oncotarget-07-51815-g001">1D ) under specific differentiating conditions in vitro.) under specific differentiating conditions in source=biomedica enhanced_caption=O: The HUMSCs, obtained from the WJ of human umbilical cord with informed consents, had a typical spindle shape and resembled fibroblasts, consistent with the morphology reported by others [12, 27]. Although a specific antigen profile of HUMSCs has not been defined, for each isolation and culture, we verified by flow cytometry that the isolated cells were positive for the mesenchymal markers CD73, CD90 and CD105 (Figure ="fig" "oncotarget-07-51815-g001">1A ) and negative for typical hematopoietic antigens CD34, CD45 and CD19 (Figure ) and negative for typical hematopoietic antigens CD34, CD45 and CD19 (Figure ="fig" "oncotarget-07-51815-g001">1B ) as previously described [) as previously described [13]. Moreover, the HUMSCs were able to undergo adipogenesis (Figure ="fig" "oncotarget-07-51815-g001">1C ) and osteogenesis (Figure ) and osteogenesis (Figure ="fig" "oncotarget-07-51815-g001">1D ) under specific differentiating conditions in vitro.) under specific differentiating conditions think=<think>Visual findings present in image → Clinical correlation needed → ICD D49.9 assigned → Moderate uncertainty due to limited context</think> icd_code=D49.9 uncertainty=medium modality=multi-modal demographic=25yo White male
|
file_name=biomedica_00642464.jpg caption=Maillard reaction can create linkages between the amino groups of proteins and the carbonyl groups of reducing sugars present in a reacting mixture. This reaction can be evaluated by determining the degree of substitution (DS) of the amino groups with the carbonyl groups. The DS of ODF-SPI conjugates as shown in ="fig" "foods-09-00143-g001">Figure 1 indicated maximum attainment at 12 h, possibly the appropriate glycation time to spatially conform soy protein for the exposure of its active sites of arginine, histidine, lysine, phenylalanine, tyrosine, leucine and asparagine residues as later found ( indicated maximum attainment at 12 h, possibly the appropriate glycation time to spatially conform soy protein for the exposure of its active sites of arginine, histidine, lysine, phenylalanine, tyrosine, leucine and asparagine residues as later found (Table 1). A longer time of heating could have caused protein polymerization and reorientation of reactive amino groups, which could be hiding source=biomedica enhanced_caption=O: Maillard reaction can create linkages between the amino groups of proteins and the carbonyl groups of reducing sugars present in a reacting mixture. This reaction can be evaluated by determining the degree of substitution (DS) of the amino groups with the carbonyl groups. The DS of ODF-SPI conjugates as shown in ="fig" "foods-09-00143-g001">Figure 1 indicated maximum attainment at 12 h, possibly the appropriate glycation time to spatially conform soy protein for the exposure of its active sites of arginine, histidine, lysine, phenylalanine, tyrosine, leucine and asparagine residues as later found ( indicated maximum attainment at 12 h, possibly the appropriate glycation time to spatially conform soy protein for the exposure of its active sites of arginine, histidine, lysine, phenylalanine, tyrosine, leucine and asparagine residues as later found (Table 1). A longer time of heating could have caused protein polymerization and reorientation of reactive amino groups, which could be hid think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=39yo Middle Eastern female
|
file_name=biomedica_00181035.jpg caption=Hydrogen peroxide showed significance only in the first experiment when a higher concentration of H2O2 was observed for plants under drought for eight days, in soil water potential of −0.96 MPa ( ="fig" "biology-09-00266-g004">Figure 4 A). For each unit of soil water potential, HA). For each unit of soil water potential, H2O2 production increased by 0.47 µmol mg protein−1, with 88% of the variation explained by the soil water potential. Antioxidant agent application reduced the production of H2O2 by 0.16 µmol mg protein−1, which represents more than 25% of reduction (Table 7). In the first experiment, O2•− was reduced when only one of the products was applied, either an antioxidant agent without xenobiotic or xenobiotic without an antioxidant agent (Table 8). Control plants under −0.69 MPa presented almost 50% higher O2•− concentration than plants under the other potentials ( ="fig" "biology-09-00266-g004">Figure 4 B). The interaction table showed differences in soil water potential of source=biomedica enhanced_caption=O: Hydrogen peroxide showed significance only in the first experiment when a higher concentration of H2O2 was observed for plants under drought for eight days, in soil water potential of −0.96 MPa ( ="fig" "biology-09-00266-g004">Figure 4 A). For each unit of soil water potential, HA). For each unit of soil water potential, H2O2 production increased by 0.47 µmol mg protein−1, with 88% of the variation explained by the soil water potential. Antioxidant agent application reduced the production of H2O2 by 0.16 µmol mg protein−1, which represents more than 25% of reduction (Table 7). In the first experiment, O2•− was reduced when only one of the products was applied, either an antioxidant agent without xenobiotic or xenobiotic without an antioxidant agent (Table 8). Control plants under −0.69 MPa presented almost 50% higher O2•− concentration than plants under the other potentials ( ="fig" "biology-09-00266-g004">Figure 4 B). The interaction table showed differences in soil water potential think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=42yo Black female
|
file_name=biomedica_00114123.jpg caption=We assessed individual linguistic production abilities with the “Sentence Construction” scale of the BeSS battery designed to detect subtle language disorders in Swedish (Laakso et al., 2000; Berg et al., 2003). At each item, the task requires to semantically and syntactically process three or four words and produce a correct sentence featuring all of them in the given syntactic form. To control for general motor resources also engaged to verbalize linguistic material, we measured linguistic motor skills with the “Sentences Repetition” scale of the BeSS. At each item, participants are requested to read and repeat a sentence aloud. Importantly, in this task participants can use semantic and syntactic contents for retrieval but, contrary to the previous assessment, no further processing of verbal material is required to articulate the already well-formed sentences. Two independent judges rated participants’ performance in each scale. Reliability between raters, measured by intraclass cor source=biomedica enhanced_caption=O: We assessed individual linguistic production abilities with the “Sentence Construction” scale of the BeSS battery designed to detect subtle language disorders in Swedish (Laakso et al., 2000; Berg et al., 2003). At each item, the task requires to semantically and syntactically process three or four words and produce a correct sentence featuring all of them in the given syntactic form. To control for general motor resources also engaged to verbalize linguistic material, we measured linguistic motor skills with the “Sentences Repetition” scale of the BeSS. At each item, participants are requested to read and repeat a sentence aloud. Importantly, in this task participants can use semantic and syntactic contents for retrieval but, contrary to the previous assessment, no further processing of verbal material is required to articulate the already well-formed sentences. Two independent judges rated participants’ performance in each scale. Reliability between raters, measured by intraclass think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=36yo Indigenous female
|
file_name=biomedica_00192616.jpg caption=A second series was studied where the distance between the oxygen atoms is varied by the number of methylene units between the alcohol end-groups in the diols [93,94]. Here n = 1–8 ( ="fig" "materials-02-01558-g006">Figure 6 ). Since the differentiating factor is the number of methylene units separating the alcohol groups, this series is referred to as the methylene series. Solubility of the diol in water is the limiting factor with respect to the length of the diol that could be used. Thus, the 1,8-octanediol was only water soluble with heating so was the longest diol employed with 1,9-nonanediol not soluble even with heating. ). Since the differentiating factor is the number of methylene units separating the alcohol groups, this series is referred to as the methylene series. Solubility of the diol in water is the limiting factor with respect to the length of the diol that could be used. Thus, the 1,8-octanediol was only water soluble with heating so was the longest diol employed with source=biomedica enhanced_caption=O: A second series was studied where the distance between the oxygen atoms is varied by the number of methylene units between the alcohol end-groups in the diols [93,94]. Here n = 1–8 ( ="fig" "materials-02-01558-g006">Figure 6 ). Since the differentiating factor is the number of methylene units separating the alcohol groups, this series is referred to as the methylene series. Solubility of the diol in water is the limiting factor with respect to the length of the diol that could be used. Thus, the 1,8-octanediol was only water soluble with heating so was the longest diol employed with 1,9-nonanediol not soluble even with heating. ). Since the differentiating factor is the number of methylene units separating the alcohol groups, this series is referred to as the methylene series. Solubility of the diol in water is the limiting factor with respect to the length of the diol that could be used. Thus, the 1,8-octanediol was only water soluble with heating so was the longest diol employed w think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=55yo Hispanic male
|
file_name=biomedica_00109437.jpg caption=NDP-α-MSH induced a marked diuretic effect as evidenced by a change in body weight ( ="fig" "pone.0072857.g001">Figure <bold>1A</bold> ). Body composition analysis revealed that the NDP-α-MSH-evoked weight reduction is exclusively attributable to a loss in total body water (1A ). Body composition analysis revealed that the NDP-α-MSH-evoked weight reduction is exclusively attributable to a loss in total body water (Figure S1 ). The reduction in body weight occurred in a dose-dependent manner ( ="fig" "pone.0072857.g001">Figure <bold>1B</bold> ). Pretreatment with the MC3/4-R receptor antagonist SHU9119 prevented the NDP-α-MSH-induced diuresis (1B ). Pretreatment with the MC3/4-R receptor antagonist SHU9119 prevented the NDP-α-MSH-induced diuresis ( ="fig" "pone.0072857.g001">Figure <bold>1C</bold> ). Supporting these findings, 24-h urine volume was increased by NDP-α-MSH administration (1C ). Supporting these findings, 24-h urine volume was increased by NDP-α-MSH administration ( ="fig" source=biomedica enhanced_caption=O: NDP-α-MSH induced a marked diuretic effect as evidenced by a change in body weight ( ="fig" "pone.0072857.g001">Figure <bold>1A</bold> ). Body composition analysis revealed that the NDP-α-MSH-evoked weight reduction is exclusively attributable to a loss in total body water (1A ). Body composition analysis revealed that the NDP-α-MSH-evoked weight reduction is exclusively attributable to a loss in total body water (Figure S1 ). The reduction in body weight occurred in a dose-dependent manner ( ="fig" "pone.0072857.g001">Figure <bold>1B</bold> ). Pretreatment with the MC3/4-R receptor antagonist SHU9119 prevented the NDP-α-MSH-induced diuresis (1B ). Pretreatment with the MC3/4-R receptor antagonist SHU9119 prevented the NDP-α-MSH-induced diuresis ( ="fig" "pone.0072857.g001">Figure <bold>1C</bold> ). Supporting these findings, 24-h urine volume was increased by NDP-α-MSH administration (1C ). Supporting these findings, 24-h urine volume was increased by NDP-α-MSH administration ( ="f think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=48yo Middle Eastern male
|
file_name=biomedica_00592427.jpg caption=For PC, the AX-75604378 SNP located on GGA10 was significantly associated with PC values measured for wavelengths ranging from 465 to 510 nm (Fig. "12711_2015_170_Fig3_HTML" ="fig">3 ). Figure ). Figure "12711_2015_170_Fig3_HTML" ="fig">3 shows the Manhattan plot and Q–Q plot for PC measured at 485 nm. The Q–Q plot shows a strong deviation from the distribution under the null hypothesis, which indicates the presence of a strong association between the SNP and PC values (See Additional file shows the Manhattan plot and Q–Q plot for PC measured at 485 nm. The Q–Q plot shows a strong deviation from the distribution under the null hypothesis, which indicates the presence of a strong association between the SNP and PC values (See Additional file 8: Figure S2). The associated SNP explains between 2.1 and 2.3 % of the total variance depending on the measured wavelength (See Additional file 6: Table S6). The AX-75604378 SNP is a non-synonymous polymorphism present in the MAN2C1 gene.Fig. 3Manh source=biomedica enhanced_caption=O: For PC, the AX-75604378 SNP located on GGA10 was significantly associated with PC values measured for wavelengths ranging from 465 to 510 nm (Fig. "12711_2015_170_Fig3_HTML" ="fig">3 ). Figure ). Figure "12711_2015_170_Fig3_HTML" ="fig">3 shows the Manhattan plot and Q–Q plot for PC measured at 485 nm. The Q–Q plot shows a strong deviation from the distribution under the null hypothesis, which indicates the presence of a strong association between the SNP and PC values (See Additional file shows the Manhattan plot and Q–Q plot for PC measured at 485 nm. The Q–Q plot shows a strong deviation from the distribution under the null hypothesis, which indicates the presence of a strong association between the SNP and PC values (See Additional file 8: Figure S2). The associated SNP explains between 2.1 and 2.3 % of the total variance depending on the measured wavelength (See Additional file 6: Table S6). The AX-75604378 SNP is a non-synonymous polymorphism present in the MAN2C1 gene.Fig. 3M think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=48yo Middle Eastern male
|
file_name=biomedica_00249520.jpg caption=Precontrast T1 values in the left ventricle and myocardium were in the range 1493–1818 ms and 1099–1124 ms, respectively. Precontrast T2 values in the left ventricle and myocardium were in the range 117–158 ms and 43–47 ms, respectively. Calculated gadofosveset and albumin concentrations in the left ventricle and myocardium are shown in Figure ="fig" "mrm0073-0244-f4">4 , with data for all seven volunteers plotted against time from first bolus administration. The models for calculating gadofosveset (Eq. [, with data for all seven volunteers plotted against time from first bolus administration. The models for calculating gadofosveset (Eq. [8]) and albumin (Eq. [13]) concentrations used the 3.0T (PBS/HSA) relaxivity values shown in Table 2. Precontrast T1 and T2 values generally correlate well with literature values (47–49), although longer T2 values in blood have been quoted elsewhere (50). Combining data from seven volunteers with images acquired at a range of time points gave remarkab source=biomedica enhanced_caption=O: Precontrast T1 values in the left ventricle and myocardium were in the range 1493–1818 ms and 1099–1124 ms, respectively. Precontrast T2 values in the left ventricle and myocardium were in the range 117–158 ms and 43–47 ms, respectively. Calculated gadofosveset and albumin concentrations in the left ventricle and myocardium are shown in Figure ="fig" "mrm0073-0244-f4">4 , with data for all seven volunteers plotted against time from first bolus administration. The models for calculating gadofosveset (Eq. [, with data for all seven volunteers plotted against time from first bolus administration. The models for calculating gadofosveset (Eq. [8]) and albumin (Eq. [13]) concentrations used the 3.0T (PBS/HSA) relaxivity values shown in Table 2. Precontrast T1 and T2 values generally correlate well with literature values (47–49), although longer T2 values in blood have been quoted elsewhere (50). Combining data from seven volunteers with images acquired at a range of time points gave remar think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=25yo White male
|
file_name=biomedica_00670931.jpg caption=Previous studies have shown that Th17 cells and IL-17A play important roles in CS-induced pulmonary inflammation [43, 44]. In the present study, the percentage of Th17 cells (CD4+IL-17A+) was significantly enhanced in the HLN and spleen of CS-injured mice compared to those of saline-treated mice; this effect was reversed by DHI treatment (Figures ="fig" "MI2019-3427053.004">4(a) –– ="fig" "MI2019-3427053.004">4(d) ). IL-17A levels in the BALF were also reduced (). IL-17A levels in the BALF were also reduced ( ="fig" "MI2019-3427053.004">Figure 4(e) ). In addition, the expression levels of the Th17 nuclear transcription factor ROR-). In addition, the expression levels of the Th17 nuclear transcription factor ROR-γt were decreased following DHI treatment (Figures ="fig" "MI2019-3427053.004">4(f) and and ="fig" "MI2019-3427053.004">4(g) ). These findings suggested that the Th17 immune response was alleviated by DHI treatment at the inflammatory stage of silicosis.). These findings suggest source=biomedica enhanced_caption=O: Previous studies have shown that Th17 cells and IL-17A play important roles in CS-induced pulmonary inflammation [43, 44]. In the present study, the percentage of Th17 cells (CD4+IL-17A+) was significantly enhanced in the HLN and spleen of CS-injured mice compared to those of saline-treated mice; this effect was reversed by DHI treatment (Figures ="fig" "MI2019-3427053.004">4(a) –– ="fig" "MI2019-3427053.004">4(d) ). IL-17A levels in the BALF were also reduced (). IL-17A levels in the BALF were also reduced ( ="fig" "MI2019-3427053.004">Figure 4(e) ). In addition, the expression levels of the Th17 nuclear transcription factor ROR-). In addition, the expression levels of the Th17 nuclear transcription factor ROR-γt were decreased following DHI treatment (Figures ="fig" "MI2019-3427053.004">4(f) and and ="fig" "MI2019-3427053.004">4(g) ). These findings suggested that the Th17 immune response was alleviated by DHI treatment at the inflammatory stage of silicosis.). These findings sugg think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=71yo Asian male
|
file_name=biomedica_00077512.jpg caption=AAV‐ie‐mediated GPS overexpression enhanced the maturation of Atoh1‐mediated HC‐like cell regeneration in vivo. A) Experimental design diagram. All the AAVs were delivered to the mice's left ear, dose: 2.5E9 GCs per ear, then the cochleae were obtained at P15. B) The immunofluorescence images of FM1‐43 and Myosin7a signals in the basal, middle, and apical turns of the ear from P15 mice injected with AAV‐Atoh1, AAV‐GPA, and AAV‐GPAS. Red: FM1‐43, cyan: Myosin7a. Scale bar, 40 µm. C) The signal intensity of FM1‐43 in ear transduced by AAV‐Atoh1, AAV‐GPA, and AAV‐GPAS, respectively, corresponding to (B). Raw results from 3 replicated experiments, error bars are ±SEM. **** p < 0.0001. D) Example membrane potentials of native HCs and Atoh1‐OE (overexpression), GPA‐OE, and GPAS‐OE HC‐like cells from P15 mice recorded in a current‐clamp mode. The initial calcium spike is plotted as a red line and highlighted with a red arrow. The confocal images of HC‐like cells after electrophysiological rec source=biomedica enhanced_caption=O: AAV‐ie‐mediated GPS overexpression enhanced the maturation of Atoh1‐mediated HC‐like cell regeneration in vivo. A) Experimental design diagram. All the AAVs were delivered to the mice's left ear, dose: 2.5E9 GCs per ear, then the cochleae were obtained at P15. B) The immunofluorescence images of FM1‐43 and Myosin7a signals in the basal, middle, and apical turns of the ear from P15 mice injected with AAV‐Atoh1, AAV‐GPA, and AAV‐GPAS. Red: FM1‐43, cyan: Myosin7a. Scale bar, 40 µm. C) The signal intensity of FM1‐43 in ear transduced by AAV‐Atoh1, AAV‐GPA, and AAV‐GPAS, respectively, corresponding to (B). Raw results from 3 replicated experiments, error bars are ±SEM. **** p < 0.0001. D) Example membrane potentials of native HCs and Atoh1‐OE (overexpression), GPA‐OE, and GPAS‐OE HC‐like cells from P15 mice recorded in a current‐clamp mode. The initial calcium spike is plotted as a red line and highlighted with a red arrow. The confocal images of HC‐like cells after electrophysiological think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=45yo Black male
|
file_name=biomedica_00284904.jpg caption=The ages of the mothers and fathers were highly correlated in our sample (Figure ="fig" "1471-2350-12-47-2">2 ; Spearman rho = 0.75, p = 2 × 10; Spearman rho = 0.75, p = 2 × 10-17). As a consequence, it would be extremely difficult to distinguish between the effects of maternal and paternal age. This is particularly the case given that there are only 31 cases of an age difference ≥ 5 years and 7 cases of an age difference ≥ 10 years, providing little statistical power to examine these subsets as a unique category. The relative strength of the relationship between CpG methylation and parental ages can be qualitatively assessed by examining the relative magnitude of the correlation between methylation levels and the ages of the 89 mothers and fathers for which we have the ages of both. With only 89 observations, the power to achieve genome-wide significance is reduced. For paternal age, there are 6 correlations with a p value ≤ 10-4 (84 at p ≤ 10-3), while for maternal age there is one C source=biomedica enhanced_caption=O: The ages of the mothers and fathers were highly correlated in our sample (Figure ="fig" "1471-2350-12-47-2">2 ; Spearman rho = 0.75, p = 2 × 10; Spearman rho = 0.75, p = 2 × 10-17). As a consequence, it would be extremely difficult to distinguish between the effects of maternal and paternal age. This is particularly the case given that there are only 31 cases of an age difference ≥ 5 years and 7 cases of an age difference ≥ 10 years, providing little statistical power to examine these subsets as a unique category. The relative strength of the relationship between CpG methylation and parental ages can be qualitatively assessed by examining the relative magnitude of the correlation between methylation levels and the ages of the 89 mothers and fathers for which we have the ages of both. With only 89 observations, the power to achieve genome-wide significance is reduced. For paternal age, there are 6 correlations with a p value ≤ 10-4 (84 at p ≤ 10-3), while for maternal age there is on think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=67yo Asian female
|
file_name=biomedica_00183221.jpg caption=Concentration-dependent effect of bradykinin (BK) on mobilization of [Ca2+]i in normal, primary h-CM cells. Fluorescent dye-loaded h-CM cells were exposed to different concentrations of BK and the changes in relative fluorescence units (RFUs), indicating changes in levels of [Ca2+]i, monitored over time ( ="fig" "mv-v19-1356-f3">Figure 3A ). The peak responses to various BK concentrations were then used to construct the concentration-response curves. Other BK-related peptides were tested in the same manner and their concentration-response curves plotted (e.g., data from a representative experiment; ). The peak responses to various BK concentrations were then used to construct the concentration-response curves. Other BK-related peptides were tested in the same manner and their concentration-response curves plotted (e.g., data from a representative experiment; ="fig" "mv-v19-1356-f3">Figure 3B ). Agonist potency data from many such experiments were obtained and are shown in ). Agonist po source=biomedica enhanced_caption=O: Concentration-dependent effect of bradykinin (BK) on mobilization of [Ca2+]i in normal, primary h-CM cells. Fluorescent dye-loaded h-CM cells were exposed to different concentrations of BK and the changes in relative fluorescence units (RFUs), indicating changes in levels of [Ca2+]i, monitored over time ( ="fig" "mv-v19-1356-f3">Figure 3A ). The peak responses to various BK concentrations were then used to construct the concentration-response curves. Other BK-related peptides were tested in the same manner and their concentration-response curves plotted (e.g., data from a representative experiment; ). The peak responses to various BK concentrations were then used to construct the concentration-response curves. Other BK-related peptides were tested in the same manner and their concentration-response curves plotted (e.g., data from a representative experiment; ="fig" "mv-v19-1356-f3">Figure 3B ). Agonist potency data from many such experiments were obtained and are shown in ). Agonist think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=25yo White male
|
file_name=biomedica_00212297.jpg caption=Alkaloids identified from Selaginella. (A) N-methyltyramine derivatives: hordenine (103), hordenine-O-α-rhamnopyranoside (104), N-methyltyramine-O-α-rhamnopyranoside (105), hordenine-O-[(6-O-cinnamoyl)-O-β-glucopyranosyl]-α-rhamnopyranoside (106), hordenine-O-[(6-O-p-coumaroyl)-O-β-glucopyranosyl]-α-rhamnopyranoside (107). (B) Hydroxycinnamoyl polyamine alkaloids: paucine (108), paucine 3′-β-D-glucopyranoside (109), N1-cis-p-coumaroylagmatine (110). source=biomedica enhanced_caption=O: Alkaloids identified from Selaginella. (A) N-methyltyramine derivatives: hordenine (103), hordenine-O-α-rhamnopyranoside (104), N-methyltyramine-O-α-rhamnopyranoside (105), hordenine-O-[(6-O-cinnamoyl)-O-β-glucopyranosyl]-α-rhamnopyranoside (106), hordenine-O-[(6-O-p-coumaroyl)-O-β-glucopyranosyl]-α-rhamnopyranoside (107). (B) Hydroxycinnamoyl polyamine alkaloids: paucine (108), paucine 3′-β-D-glucopyranoside (109), N1-cis-p-coumaroylagmatine (110). A: Clinical findings require correlation. P: Further evaluation recommended. think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=25yo White male
|
file_name=biomedica_00285582.jpg caption=We found support for multiple direct exogenous effects contributing to each hormone pathway model (Table 1). Local population density affected CORTser and TT4ser reservoirs similarly, wherein individuals experiencing greater exposure to conspecifics had higher basal levels of both hormones. Sex differences in testosterone were also already present, with male pups having higher TESTser. Considering maternal effects, only maternal SMI had a strong influence on pup hormone profiles; females in better body condition produced pups with lower CORTser and TT4ser but higher TESTser (Fig. "442_2020_4815_Fig3_HTML" ="fig">3 ). Although there was no direct covariation between any maternal traits and pup Δ SMI (Table ). Although there was no direct covariation between any maternal traits and pup Δ SMI (Table 2), pups with faster relative increases in body condition (i.e. greater Δ SMI) had higher CORTser and TT3ser values.Table 1Path coefficients (path coef.) derived from 4 different structural eq source=biomedica enhanced_caption=O: We found support for multiple direct exogenous effects contributing to each hormone pathway model (Table 1). Local population density affected CORTser and TT4ser reservoirs similarly, wherein individuals experiencing greater exposure to conspecifics had higher basal levels of both hormones. Sex differences in testosterone were also already present, with male pups having higher TESTser. Considering maternal effects, only maternal SMI had a strong influence on pup hormone profiles; females in better body condition produced pups with lower CORTser and TT4ser but higher TESTser (Fig. "442_2020_4815_Fig3_HTML" ="fig">3 ). Although there was no direct covariation between any maternal traits and pup Δ SMI (Table ). Although there was no direct covariation between any maternal traits and pup Δ SMI (Table 2), pups with faster relative increases in body condition (i.e. greater Δ SMI) had higher CORTser and TT3ser values.Table 1Path coefficients (path coef.) derived from 4 different structural think=<think>Visual findings present in image → Clinical correlation needed → ICD D49.9 assigned → Moderate uncertainty due to limited context</think> icd_code=D49.9 uncertainty=medium modality=multi-modal demographic=25yo White male
|
file_name=biomedica_00399185.jpg caption=The qPCR analysis was performed using an ABI Prism 7000 sequence detection system (Applied Biosystems, USA) with SYBR Green PCR Master Mix (Applied Biosystems, USA). As a positive control, several concentrations of phMGFP (0.01, 0.05, 0.1, 0.5, and 1 ng) were prepared. Each test was performed in triplicate. The quantity of delivered plasmid was ~ 0.014 pg obtained by comparing "gr5" ="fig">Fig. 5 (a) and (b). In each group, three different Au NWIs were used to qPCR analysis. *(a) and (b). In each group, three different Au NWIs were used to qPCR analysis. *P < 0.05 versus (a) injected Au NWI.Fig. 5Amount of delivered plasmid (pg) by a Au NWI. Each quantity of plasmid from Au NWIs in (a) and (b) in "gr4" ="fig">Fig. 4 is shown; (a) injected Au NWIs which were used to inject and deliver plasmid (magenta) and (b) uninjected Au NWIs which were not used to deliver the plasmid (blue). is shown; (a) injected Au NWIs which were used to inject and deliver plasmid (magenta) and (b) uninjected Au source=biomedica enhanced_caption=O: The qPCR analysis was performed using an ABI Prism 7000 sequence detection system (Applied Biosystems, USA) with SYBR Green PCR Master Mix (Applied Biosystems, USA). As a positive control, several concentrations of phMGFP (0.01, 0.05, 0.1, 0.5, and 1 ng) were prepared. Each test was performed in triplicate. The quantity of delivered plasmid was ~ 0.014 pg obtained by comparing "gr5" ="fig">Fig. 5 (a) and (b). In each group, three different Au NWIs were used to qPCR analysis. *(a) and (b). In each group, three different Au NWIs were used to qPCR analysis. *P < 0.05 versus (a) injected Au NWI.Fig. 5Amount of delivered plasmid (pg) by a Au NWI. Each quantity of plasmid from Au NWIs in (a) and (b) in "gr4" ="fig">Fig. 4 is shown; (a) injected Au NWIs which were used to inject and deliver plasmid (magenta) and (b) uninjected Au NWIs which were not used to deliver the plasmid (blue). is shown; (a) injected Au NWIs which were used to inject and deliver plasmid (magenta) and (b) uninjected think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=28yo South Asian female
|
file_name=biomedica_00324985.jpg caption=The patient was primarily admitted to a designated Covid-19 ward for further observation and oxygen therapy. Due to severe hypoxemic respiratory failure within 24 h after admission, he was immediately transferred to the intensive care unit (ICU) where he was intubated. On the 5th day of ICU admission (T0), the patient developed a high fever accompanied with an increase in inflammatory parameters (Table 1). Hemodynamic parameters did not indicate an unstable course (Table 1). Microcirculatory monitoring was carried out sublingually using Cytocam-IDF imaging (CytoCam, Braedius Medical, Huizen, The Netherlands). Image analysis which was performed offline using MicroTools, showed an increase in microcirculatory density (total vessel density and perfused vessel density) and perfusion parameters (proportion of perfused vessels and microvascular mean flow index) as well as in red blood cell (RBC) velocity (Table 2). Subsequent CT-scan demonstrated extensive subcutaneous emphysema and pneumome source=biomedica enhanced_caption=O: The patient was primarily admitted to a designated Covid-19 ward for further observation and oxygen therapy. Due to severe hypoxemic respiratory failure within 24 h after admission, he was immediately transferred to the intensive care unit (ICU) where he was intubated. On the 5th day of ICU admission (T0), the patient developed a high fever accompanied with an increase in inflammatory parameters (Table 1). Hemodynamic parameters did not indicate an unstable course (Table 1). Microcirculatory monitoring was carried out sublingually using Cytocam-IDF imaging (CytoCam, Braedius Medical, Huizen, The Netherlands). Image analysis which was performed offline using MicroTools, showed an increase in microcirculatory density (total vessel density and perfused vessel density) and perfusion parameters (proportion of perfused vessels and microvascular mean flow index) as well as in red blood cell (RBC) velocity (Table 2). Subsequent CT-scan demonstrated extensive subcutaneous emphysema and pneum think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=28yo South Asian female
|
file_name=biomedica_00050994.jpg caption=Studies were assessed for eligibility by two independent reviewers and all conflicts were resolved by a third independent reviewer. Publication date, phenotype, and cohort information were extracted from each publication. If multiple phenotypes of interest were analyzed in the same study, information was included in both phenotype categories. The number of samples per ancestry was extracted manually from each study. We looked at seven ancestry groupings: European (EUR), East Asian (EAS), Middle-Eastern (MDE), African (AFR), African American and Caribbean (AAC), Latino and indigenous Americas populations (AMR), and South Asian (SAS). A PRISMA diagram of our filtering process can be found in "nihpp-2024.01.08.24301007v1-f0001" ="fig">Figure 1 . All 123 studies passing our filters can be found in . All 123 studies passing our filters can be found in Supplementary Table 2. source=biomedica enhanced_caption=O: Studies were assessed for eligibility by two independent reviewers and all conflicts were resolved by a third independent reviewer. Publication date, phenotype, and cohort information were extracted from each publication. If multiple phenotypes of interest were analyzed in the same study, information was included in both phenotype categories. The number of samples per ancestry was extracted manually from each study. We looked at seven ancestry groupings: European (EUR), East Asian (EAS), Middle-Eastern (MDE), African (AFR), African American and Caribbean (AAC), Latino and indigenous Americas populations (AMR), and South Asian (SAS). A PRISMA diagram of our filtering process can be found in "nihpp-2024.01.08.24301007v1-f0001" ="fig">Figure 1 . All 123 studies passing our filters can be found in . All 123 studies passing our filters can be found in Supplementary Table 2. A: Clinical findings require correlation. P: Further evaluation recommended. think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=32yo Hispanic female
|
file_name=biomedica_00539804.jpg caption=This study was conducted in the Lincoln Lake CEAP watershed, a 32 km2 agricultural watershed within the Illinois River basin located in Northwest Arkansas and Eastern Oklahoma ( ="fig" "ijerph-11-02992-g001">Figure 1 ). The average slope in the watershed is 6%. The elevation ranges from 365 to 487 m with a mean elevation of 429 m. The major soil series in the watershed are Enders gravelly loam, Hector-Mountainburg gravelly fine sandy loam, Captina silt loam and Linker loam, which account for 23%, 21%, 13% and 12% of the entire area, respectively. An average annual precipitation of 1,231 mm was observed during 1990–2002 with the highest average monthly precipitation (158.3 mm) in April and the lowest average monthly precipitation (74 mm) in January. The average maximum and minimum temperature during 1990–2002 were 20.1 °C and 8.7 °C, respectively. Excessive nutrient losses due to improper litter application and grazing activity on pasture lands has been one of the main environmental iss source=biomedica enhanced_caption=O: This study was conducted in the Lincoln Lake CEAP watershed, a 32 km2 agricultural watershed within the Illinois River basin located in Northwest Arkansas and Eastern Oklahoma ( ="fig" "ijerph-11-02992-g001">Figure 1 ). The average slope in the watershed is 6%. The elevation ranges from 365 to 487 m with a mean elevation of 429 m. The major soil series in the watershed are Enders gravelly loam, Hector-Mountainburg gravelly fine sandy loam, Captina silt loam and Linker loam, which account for 23%, 21%, 13% and 12% of the entire area, respectively. An average annual precipitation of 1,231 mm was observed during 1990–2002 with the highest average monthly precipitation (158.3 mm) in April and the lowest average monthly precipitation (74 mm) in January. The average maximum and minimum temperature during 1990–2002 were 20.1 °C and 8.7 °C, respectively. Excessive nutrient losses due to improper litter application and grazing activity on pasture lands has been one of the main environmental think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=52yo Indigenous male
|
file_name=pmcvqa_00142544.jpg caption=Clinical Question: What is shown in image (E)? Answer: Bone cylinder μCT scan after applying a two-level segmentation Otsu threshold. source=pmcvqa enhanced_caption=O: Clinical Question: What is shown in image (E)? Answer: Bone cylinder μCT scan after applying a two-level segmentation Otsu threshold. A: Clinical findings require correlation. P: Further evaluation recommended. think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=radiology demographic=64yo Pacific Islander male
|
file_name=biomedica_00723214.jpg caption=To determine whether HNF4α and CYP2E1 are coordinately regulated in vivo, immunohistochemical (IHC) staining was performed in normal and HCC tissue. Morphological and IHC changes of liver tissues are shown in ="fig" "pone.0107913.g005">Fig. 5 . HE showed the normal structure of liver tissue (panel 1), adjacent paracarcinoma tissue (panel 2) and typical carcinoma tissue (panel 3). HBx staining showed that normal liver tissue is absent of HBV infection (panel 4), whereas intensive HBx expression was observed in HBV positive HCC liver tissue (panel 6), and expression of HBx was much higher compared to the paracarcinoma area (panel 5). Conversely, HNF-4α levels were inversely correlated with HBx expression (panel 7 to panel 9) and positively correlated with CYP2E1 expression (panel 10 to panel 12). These results provide in vivo evidence for a synergistic change of HNF-4α and CYP2E1 expression under chronic HBV infection in human livers.. HE showed the normal structure of liver tissue (pane source=biomedica enhanced_caption=O: To determine whether HNF4α and CYP2E1 are coordinately regulated in vivo, immunohistochemical (IHC) staining was performed in normal and HCC tissue. Morphological and IHC changes of liver tissues are shown in ="fig" "pone.0107913.g005">Fig. 5 . HE showed the normal structure of liver tissue (panel 1), adjacent paracarcinoma tissue (panel 2) and typical carcinoma tissue (panel 3). HBx staining showed that normal liver tissue is absent of HBV infection (panel 4), whereas intensive HBx expression was observed in HBV positive HCC liver tissue (panel 6), and expression of HBx was much higher compared to the paracarcinoma area (panel 5). Conversely, HNF-4α levels were inversely correlated with HBx expression (panel 7 to panel 9) and positively correlated with CYP2E1 expression (panel 10 to panel 12). These results provide in vivo evidence for a synergistic change of HNF-4α and CYP2E1 expression under chronic HBV infection in human livers.. HE showed the normal structure of liver tissue (p think=<think>Visual findings present in image → Clinical correlation needed → ICD C80.1 assigned → Moderate uncertainty due to limited context</think> icd_code=C80.1 uncertainty=medium modality=multi-modal demographic=55yo Hispanic male
|
file_name=biomedica_00671291.jpg caption=Overall, nonserpentine species were generally more plastic than the serpentine species, and traits associated with growth rate, biomass accumulation, and nutrient pools (particularly total N pools) were more plastic than those associated with instantaneous physiological measures or green and senesced leaf N ( "fpls-10-00505-g006" ="fig">Figures 6A –– "fpls-10-00505-g006" ="fig">K ). Additionally, qualitative inspection of PIv values suggested there was some evidence that congener pairs were similarly plastic for some traits, particularly RGR, photosynthetic P use efficiency, and total nutrient pools (). Additionally, qualitative inspection of PIv values suggested there was some evidence that congener pairs were similarly plastic for some traits, particularly RGR, photosynthetic P use efficiency, and total nutrient pools ( "fpls-10-00505-g006" ="fig">Figures 6A ,, "fpls-10-00505-g006" ="fig">H ,, "fpls-10-00505-g006" ="fig">J ,, "fpls-10-00505-g006" ="fig">K ).). source=biomedica enhanced_caption=O: Overall, nonserpentine species were generally more plastic than the serpentine species, and traits associated with growth rate, biomass accumulation, and nutrient pools (particularly total N pools) were more plastic than those associated with instantaneous physiological measures or green and senesced leaf N ( "fpls-10-00505-g006" ="fig">Figures 6A –– "fpls-10-00505-g006" ="fig">K ). Additionally, qualitative inspection of PIv values suggested there was some evidence that congener pairs were similarly plastic for some traits, particularly RGR, photosynthetic P use efficiency, and total nutrient pools (). Additionally, qualitative inspection of PIv values suggested there was some evidence that congener pairs were similarly plastic for some traits, particularly RGR, photosynthetic P use efficiency, and total nutrient pools ( "fpls-10-00505-g006" ="fig">Figures 6A ,, "fpls-10-00505-g006" ="fig">H ,, "fpls-10-00505-g006" ="fig">J ,, "fpls-10-00505-g006" ="fig">K ).). A: Clinical findings think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=45yo Black male
|
file_name=biomedica_00146836.jpg caption=The absolute output can be calibrated in two ways (see "jresv80an3p401_a1bf13" ="fig">fig. 13 ): ): the luminescent output is measured with a calibrated detector (A/W · cm2), e.g., a 150 CV or 150 UV photocell (calibration National Physical Laboratory, Teddington, England).the luminescent output is compared with the output of a calibrated standard lamp, e.g., a 200 W or 1000 W tungsten - halogen lamp; calibrated by the National Bureau of Standards in Washington, D.C. (W/nm · cm2). In this case the diode to be measured is replaced by a BaSO4-coated screen S. source=biomedica enhanced_caption=O: The absolute output can be calibrated in two ways (see "jresv80an3p401_a1bf13" ="fig">fig. 13 ): ): the luminescent output is measured with a calibrated detector (A/W · cm2), e.g., a 150 CV or 150 UV photocell (calibration National Physical Laboratory, Teddington, England).the luminescent output is compared with the output of a calibrated standard lamp, e.g., a 200 W or 1000 W tungsten - halogen lamp; calibrated by the National Bureau of Standards in Washington, D.C. (W/nm · cm2). In this case the diode to be measured is replaced by a BaSO4-coated screen S. A: Clinical findings require correlation. P: Further evaluation recommended. think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=36yo Indigenous female
|
file_name=biomedica_00428118.jpg caption=Figure "41598_2019_53203_Fig1_HTML" ="fig">1 plots the frequency of suicides by the age in days. The horizontal axis denotes the scale of age in days from 5478 (15 plots the frequency of suicides by the age in days. The horizontal axis denotes the scale of age in days from 5478 (15th birthday) to 32872 (90th birthday) days. For readability, we displayed the birthdays between ages 15 and 90 in five-year intervals using labels of age in years. For example, we used 15 instead of 5478 to mark the 15th birthday, which occur 5478 days after birth. The vertical dashed lines denote the birthdays between ages 20 and 90 in five-year intervals. The red diamonds denote the frequency of suicides on milestone birthdays at ages from 20 and 30 to 90 and the blue circles denote the frequency of suicides on non-milestone birthdays. All other black dots denote the frequency on non-birthdays. Figure "41598_2019_53203_Fig1_HTML" ="fig">1 shows visible jumps on the milestone birthday ages of 20, 40, and 60; source=biomedica enhanced_caption=O: Figure "41598_2019_53203_Fig1_HTML" ="fig">1 plots the frequency of suicides by the age in days. The horizontal axis denotes the scale of age in days from 5478 (15 plots the frequency of suicides by the age in days. The horizontal axis denotes the scale of age in days from 5478 (15th birthday) to 32872 (90th birthday) days. For readability, we displayed the birthdays between ages 15 and 90 in five-year intervals using labels of age in years. For example, we used 15 instead of 5478 to mark the 15th birthday, which occur 5478 days after birth. The vertical dashed lines denote the birthdays between ages 20 and 90 in five-year intervals. The red diamonds denote the frequency of suicides on milestone birthdays at ages from 20 and 30 to 90 and the blue circles denote the frequency of suicides on non-milestone birthdays. All other black dots denote the frequency on non-birthdays. Figure "41598_2019_53203_Fig1_HTML" ="fig">1 shows visible jumps on the milestone birthday ages of 20, 40, and think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=71yo Asian male
|
file_name=biomedica_00358153.jpg caption=Error Bar diagram of the studied organochlorine pesticides over all water and sediment samples based on the mean of HCHs and DDTs. source=biomedica enhanced_caption=O: Error Bar diagram of the studied organochlorine pesticides over all water and sediment samples based on the mean of HCHs and DDTs. A: Clinical findings require correlation. P: Further evaluation recommended. think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=39yo Middle Eastern female
|
file_name=biomedica_00050858.jpg caption=Based on the chemical characterization of the feedstock and available studies concerning sequential separation of macroalgal compounds [39,44,48,65], a biorefinery flow sheet for Fucus spiralis biomass was designed ( "polymers-14-04106-g001" ="fig">Figure 1 ). All solvents and methods were selected taking into consideration cost effectiveness and circular economy. Thus, a sustainable, efficient and minimal-waste approach was considered. The primary biorefinery step was designed to obtain easily extractible valuable molecules, such as polyphenols and saccharides.). All solvents and methods were selected taking into consideration cost effectiveness and circular economy. Thus, a sustainable, efficient and minimal-waste approach was considered. The primary biorefinery step was designed to obtain easily extractible valuable molecules, such as polyphenols and saccharides. The sequence starts with green light sonication ( "polymers-14-04106-g001" ="fig">Figure 1 ) in order to separate the pol source=biomedica enhanced_caption=O: Based on the chemical characterization of the feedstock and available studies concerning sequential separation of macroalgal compounds [39,44,48,65], a biorefinery flow sheet for Fucus spiralis biomass was designed ( "polymers-14-04106-g001" ="fig">Figure 1 ). All solvents and methods were selected taking into consideration cost effectiveness and circular economy. Thus, a sustainable, efficient and minimal-waste approach was considered. The primary biorefinery step was designed to obtain easily extractible valuable molecules, such as polyphenols and saccharides.). All solvents and methods were selected taking into consideration cost effectiveness and circular economy. Thus, a sustainable, efficient and minimal-waste approach was considered. The primary biorefinery step was designed to obtain easily extractible valuable molecules, such as polyphenols and saccharides. The sequence starts with green light sonication ( "polymers-14-04106-g001" ="fig">Figure 1 ) in order to separate the think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=52yo Indigenous male
|
file_name=biomedica_00185368.jpg caption=To test whether the broad gene silencing effect is related to the pathogenicity of the NTUH-K2044 strain, we examined possible functions of the silenced genes. Importantly, the 37 genes upstream of the cps locus affected by the gene silencing effect include many regulators and multidrug efflux genes (from kp3742 to kp3747) ( ="fig" "pone.0021664.g001"> <bold>Figure 1A</bold> Figure 1A and Table S5). Since multidrug efflux pumps are known to contribute to drug resistance in Gram-negative bacteria [26], this finding led us to predict that the three mutants d3706, d3709, and d3712 would be less drug-resistant to some of the antibiotics. As shown in ="fig" "pone.0021664.g004"> <bold>Figure 4A</bold> , in the absence of antibiotics there were no significant differences in growth rates between K2044 and its mutants, confirming that CPS is important for pathogenicity but not for growth (ΔFigure 4A , in the absence of antibiotics there were no significant differences in growth rates between K2 source=biomedica enhanced_caption=O: To test whether the broad gene silencing effect is related to the pathogenicity of the NTUH-K2044 strain, we examined possible functions of the silenced genes. Importantly, the 37 genes upstream of the cps locus affected by the gene silencing effect include many regulators and multidrug efflux genes (from kp3742 to kp3747) ( ="fig" "pone.0021664.g001"> <bold>Figure 1A</bold> Figure 1A and Table S5). Since multidrug efflux pumps are known to contribute to drug resistance in Gram-negative bacteria [26], this finding led us to predict that the three mutants d3706, d3709, and d3712 would be less drug-resistant to some of the antibiotics. As shown in ="fig" "pone.0021664.g004"> <bold>Figure 4A</bold> , in the absence of antibiotics there were no significant differences in growth rates between K2044 and its mutants, confirming that CPS is important for pathogenicity but not for growth (ΔFigure 4A , in the absence of antibiotics there were no significant differences in growth rates between think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=45yo Black male
|
file_name=biomedica_00419755.jpg caption=In ="fig" "pone.0103183.g008">Figure 8 and and ="fig" "pone.0103183.g009">9 we report the prevalence and interleaving degree distributions of the best fitting model versus the observed and combinatorial ones, both on specific size sequences and aggregated case. There is some evidence that the model fits in sample data much better than combinatorial analysis, which exhibits an unrealistic symmetrical trend with center (approximately) we report the prevalence and interleaving degree distributions of the best fitting model versus the observed and combinatorial ones, both on specific size sequences and aggregated case. There is some evidence that the model fits in sample data much better than combinatorial analysis, which exhibits an unrealistic symmetrical trend with center (approximately) . Note that the model is also able to reproduce the peaks due to the one-dimensional and disjoint bursts, which represent the behavior farther from randomness. source=biomedica enhanced_caption=O: In ="fig" "pone.0103183.g008">Figure 8 and and ="fig" "pone.0103183.g009">9 we report the prevalence and interleaving degree distributions of the best fitting model versus the observed and combinatorial ones, both on specific size sequences and aggregated case. There is some evidence that the model fits in sample data much better than combinatorial analysis, which exhibits an unrealistic symmetrical trend with center (approximately) we report the prevalence and interleaving degree distributions of the best fitting model versus the observed and combinatorial ones, both on specific size sequences and aggregated case. There is some evidence that the model fits in sample data much better than combinatorial analysis, which exhibits an unrealistic symmetrical trend with center (approximately) . Note that the model is also able to reproduce the peaks due to the one-dimensional and disjoint bursts, which represent the behavior farther from randomness. A: Clinical findings require correlatio think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=48yo Middle Eastern male
|
file_name=biomedica_00042135.jpg caption=To study the displacements of the LRE piezo disk, the piezo rings O1~O7 were energized separately. The radial displacements of the sample under single-electrode-ring excitation were detected. The effect of the piezo ring radius on the peak displacement is shown in "micromachines-13-00951-g011" ="fig">Figure 11 . For comparison, the displacement results of the single-electrode-ring loading in . For comparison, the displacement results of the single-electrode-ring loading in Section 3.2 are summarized in "micromachines-13-00951-g011" ="fig">Figure 11 .. source=biomedica enhanced_caption=O: To study the displacements of the LRE piezo disk, the piezo rings O1~O7 were energized separately. The radial displacements of the sample under single-electrode-ring excitation were detected. The effect of the piezo ring radius on the peak displacement is shown in "micromachines-13-00951-g011" ="fig">Figure 11 . For comparison, the displacement results of the single-electrode-ring loading in . For comparison, the displacement results of the single-electrode-ring loading in Section 3.2 are summarized in "micromachines-13-00951-g011" ="fig">Figure 11 .. A: Clinical findings require correlation. P: Further evaluation recommended. think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=55yo Hispanic male
|
file_name=biomedica_00068890.jpg caption=Many studies have demonstrated that stem cell programming is influenced by the microenvironment [56–58]. To determine whether the phenotypic fate of vMSC-CM fusion products could be regulated by the microenvironment, following treatment with fusion media, we cultured vMSC-CM fusion products under either MSC-specific or CM-specific culture conditions and examined the incidence of fusion and morphology of MSC-CM fusion products. At days 5 and 7 following the induction of cell fusion, cocultures were probed with CM and MSC specific antibodies (anti-MF20 and anti-CD105, respectively, n = 1 replicate per sample per trial for 3 trials). At day 5, vMSC-CM cocultures contained a relatively high number of cells that expressed both MF20 and CD105 and the percentage of MF20+/CD105+ cells relative to the total cell number was significantly greater than that of MSC-CM cocultures for both culture conditions (P < 0.005) ( ="fig" "SCI2012-414038.003">Figure 3(a) ). Of note, the percentage of MF20). Of source=biomedica enhanced_caption=O: Many studies have demonstrated that stem cell programming is influenced by the microenvironment [56–58]. To determine whether the phenotypic fate of vMSC-CM fusion products could be regulated by the microenvironment, following treatment with fusion media, we cultured vMSC-CM fusion products under either MSC-specific or CM-specific culture conditions and examined the incidence of fusion and morphology of MSC-CM fusion products. At days 5 and 7 following the induction of cell fusion, cocultures were probed with CM and MSC specific antibodies (anti-MF20 and anti-CD105, respectively, n = 1 replicate per sample per trial for 3 trials). At day 5, vMSC-CM cocultures contained a relatively high number of cells that expressed both MF20 and CD105 and the percentage of MF20+/CD105+ cells relative to the total cell number was significantly greater than that of MSC-CM cocultures for both culture conditions (P < 0.005) ( ="fig" "SCI2012-414038.003">Figure 3(a) ). Of note, the percentage of MF20). think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=67yo Asian female
|
file_name=pmcvqa_00121492.jpg caption=Clinical Question: In panel B, what is the result of the bladder compressing the distal descending colon? Answer: A thin layer of dye between rectum and descending colon source=pmcvqa enhanced_caption=O: Clinical Question: In panel B, what is the result of the bladder compressing the distal descending colon? Answer: A thin layer of dye between rectum and descending colon A: Clinical findings require correlation. P: Further evaluation recommended. think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=radiology demographic=45yo Black male
|
file_name=biomedica_00296635.jpg caption=Phthalocyanines and their derivatives also present interesting photodynamic properties useful for the inactivation of pathogenic microorganisms. These compounds allow the incorporation of different functionalities and moieties due to their chemical versatility [104]. Strokov et al. employed a one-pot generation method for obtaining hydrophilic silicon(IV)phthalocyanine (SiPc)/PVA-based electrospun mats. Subsequently, a thermal cross-linking procedure based on esterification reaction with sebacic acid was performed ( "pharmaceutics-15-01964-g010" ="fig">Figure 10 a) [a) [105]. After electrospinning, dense networks of non-woven fibers presenting diameters in the range of 250–400 nm were fabricated ( "pharmaceutics-15-01964-g010" ="fig">Figure 10 b). The concentrations of. SiPcPEGb). The concentrations of. SiPcPEG2-NF and SiPcPy4PEG2-NF were 13.28 nmol cm−2 and 24.92 nmol cm−2, respectively. The antibacterial efficacy of PS within the matrices was assayed against S. aureus, S. warneri, an source=biomedica enhanced_caption=O: Phthalocyanines and their derivatives also present interesting photodynamic properties useful for the inactivation of pathogenic microorganisms. These compounds allow the incorporation of different functionalities and moieties due to their chemical versatility [104]. Strokov et al. employed a one-pot generation method for obtaining hydrophilic silicon(IV)phthalocyanine (SiPc)/PVA-based electrospun mats. Subsequently, a thermal cross-linking procedure based on esterification reaction with sebacic acid was performed ( "pharmaceutics-15-01964-g010" ="fig">Figure 10 a) [a) [105]. After electrospinning, dense networks of non-woven fibers presenting diameters in the range of 250–400 nm were fabricated ( "pharmaceutics-15-01964-g010" ="fig">Figure 10 b). The concentrations of. SiPcPEGb). The concentrations of. SiPcPEG2-NF and SiPcPy4PEG2-NF were 13.28 nmol cm−2 and 24.92 nmol cm−2, respectively. The antibacterial efficacy of PS within the matrices was assayed against S. aureus, S. warneri, think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=32yo Hispanic female
|
file_name=biomedica_00552824.jpg caption=We first used this composite RNA expression variable to examine the influence of potentially confounding intergroup differences in clinical and demographic characteristics on the expression levels of the top 10 genes. Stroke, age, anticoagulant status, hypertension, antihypertensive status, dyslipidaemia, history of myocardial infarction and history of atrial fibrillation were regressed against the composite RNA expression levels of the top 10 genes using multiple regression. We then performed variance decomposition via the Lindeman-Merenda-Gold (LMG) method to estimate the relative contributions of each regressor to the total variance in composite RNA expression explained by the resultant regression model.21 Stroke remained significantly associated with the composite RNA expression levels of the top 10 genes after accounting for all potentially confounding factors included in the model ( ="fig" "npjgenmed201638-f3">Figure 3a ), and was responsible for a majority of the explained varia source=biomedica enhanced_caption=O: We first used this composite RNA expression variable to examine the influence of potentially confounding intergroup differences in clinical and demographic characteristics on the expression levels of the top 10 genes. Stroke, age, anticoagulant status, hypertension, antihypertensive status, dyslipidaemia, history of myocardial infarction and history of atrial fibrillation were regressed against the composite RNA expression levels of the top 10 genes using multiple regression. We then performed variance decomposition via the Lindeman-Merenda-Gold (LMG) method to estimate the relative contributions of each regressor to the total variance in composite RNA expression explained by the resultant regression model.21 Stroke remained significantly associated with the composite RNA expression levels of the top 10 genes after accounting for all potentially confounding factors included in the model ( ="fig" "npjgenmed201638-f3">Figure 3a ), and was responsible for a majority of the explained va think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=39yo Middle Eastern female
|
file_name=biomedica_00282496.jpg caption=The ratio of myeloid to lymphoid cells has previously been associated with differences in TB disease risk in HIV-infected South African adults and susceptibility to malaria and influenza in other cohorts [37-40] and this may be another example of an outcome associated with this ratio. The gene expression profiles associated with responder infants are present pre-vaccination and show a strong overlap pre- and one day post vaccination. This suggests the baseline inflammatory profile of the infant, including the differing proportion of circulating leukocytes, is key to determining the response to vaccination. This may be influenced by genetic influences on innate immunity or environmental exposure preceding vaccination, including the response to BCG, which all infants received at birth. As MVA preferentially infects myeloid cells [41], a higher proportion of myeloid cells may lead to overall increased viral expression of Ag85A protein in infants with higher frequencies of myeloid cells. C source=biomedica enhanced_caption=O: The ratio of myeloid to lymphoid cells has previously been associated with differences in TB disease risk in HIV-infected South African adults and susceptibility to malaria and influenza in other cohorts [37-40] and this may be another example of an outcome associated with this ratio. The gene expression profiles associated with responder infants are present pre-vaccination and show a strong overlap pre- and one day post vaccination. This suggests the baseline inflammatory profile of the infant, including the differing proportion of circulating leukocytes, is key to determining the response to vaccination. This may be influenced by genetic influences on innate immunity or environmental exposure preceding vaccination, including the response to BCG, which all infants received at birth. As MVA preferentially infects myeloid cells [41], a higher proportion of myeloid cells may lead to overall increased viral expression of Ag85A protein in infants with higher frequencies of myeloid cells think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=55yo Hispanic male
|
file_name=biomedica_00680506.jpg caption=Saline-treated wounds of diabetic mice presented edematous dermis, leukocyte infiltration (predominantly by mononuclear cells), and null (or partial) formation of epidermis at day 7. In the reticular dermis, exuberant formation of granulation tissue and congested neovessels were observed ( ="fig" "fimmu-12-651740-g003"> <bold>Figure 3A</bold> ). Interestingly, ADP-treated wounds presented the epidermis regenerated and integrated to the underlying dermis, with hyperplasic suprabasal layers, and hyperkeratosis. In the dermis, there was a dense granulation tissue with inflammatory cell infiltrate comprising eosinophils, mast cells, myeloid progenitors, neutrophils, and mononuclear cells. Clop administration impaired tissue regeneration in saline-treated wounds, where denuded epidermis areas, necrotic dermis with an inflammatory infiltrate composed predominantly of polymorphonuclear cells, striking bleeding, and the absence of granulation tissue were observed. Clop administration also impa source=biomedica enhanced_caption=O: Saline-treated wounds of diabetic mice presented edematous dermis, leukocyte infiltration (predominantly by mononuclear cells), and null (or partial) formation of epidermis at day 7. In the reticular dermis, exuberant formation of granulation tissue and congested neovessels were observed ( ="fig" "fimmu-12-651740-g003"> <bold>Figure 3A</bold> ). Interestingly, ADP-treated wounds presented the epidermis regenerated and integrated to the underlying dermis, with hyperplasic suprabasal layers, and hyperkeratosis. In the dermis, there was a dense granulation tissue with inflammatory cell infiltrate comprising eosinophils, mast cells, myeloid progenitors, neutrophils, and mononuclear cells. Clop administration impaired tissue regeneration in saline-treated wounds, where denuded epidermis areas, necrotic dermis with an inflammatory infiltrate composed predominantly of polymorphonuclear cells, striking bleeding, and the absence of granulation tissue were observed. Clop administration also i think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=52yo Indigenous male
|
file_name=biomedica_00613993.jpg caption=By the Kaplan–Meier analysis, the overall PS rates after KT at 1, 5, 10, and 20 years were 96.9%, 95.1%, 92.0%, and 88.9%, respectively (Fig. ="fig" "medi-95-e4249-g004">2 A). The overall GS rates after KT at 1, 5, 10, and 20 years were 96.3%, 88.9%, 81.2%, and 67.4%, respectively (Fig. A). The overall GS rates after KT at 1, 5, 10, and 20 years were 96.3%, 88.9%, 81.2%, and 67.4%, respectively (Fig. ="fig" "medi-95-e4249-g004">2 B). The overall PS rates stratified by donor type at 1, 5, 10, and 20 years were 97.7%, 96.1%, 93.1%, and 90.3%, respectively, in living-donor kidney transplantations (LDKTs) and 94.4%, 91.6%, 88.6%, and 84.7% in DDKTs (Fig. B). The overall PS rates stratified by donor type at 1, 5, 10, and 20 years were 97.7%, 96.1%, 93.1%, and 90.3%, respectively, in living-donor kidney transplantations (LDKTs) and 94.4%, 91.6%, 88.6%, and 84.7% in DDKTs (Fig. ="fig" "medi-95-e4249-g005">3 A). The overall GS rates stratified by donor type at 1, 5, 10, and 20 years were 97.5% source=biomedica enhanced_caption=O: By the Kaplan–Meier analysis, the overall PS rates after KT at 1, 5, 10, and 20 years were 96.9%, 95.1%, 92.0%, and 88.9%, respectively (Fig. ="fig" "medi-95-e4249-g004">2 A). The overall GS rates after KT at 1, 5, 10, and 20 years were 96.3%, 88.9%, 81.2%, and 67.4%, respectively (Fig. A). The overall GS rates after KT at 1, 5, 10, and 20 years were 96.3%, 88.9%, 81.2%, and 67.4%, respectively (Fig. ="fig" "medi-95-e4249-g004">2 B). The overall PS rates stratified by donor type at 1, 5, 10, and 20 years were 97.7%, 96.1%, 93.1%, and 90.3%, respectively, in living-donor kidney transplantations (LDKTs) and 94.4%, 91.6%, 88.6%, and 84.7% in DDKTs (Fig. B). The overall PS rates stratified by donor type at 1, 5, 10, and 20 years were 97.7%, 96.1%, 93.1%, and 90.3%, respectively, in living-donor kidney transplantations (LDKTs) and 94.4%, 91.6%, 88.6%, and 84.7% in DDKTs (Fig. ="fig" "medi-95-e4249-g005">3 A). The overall GS rates stratified by donor type at 1, 5, 10, and 20 years were 97 think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=25yo White male
|
file_name=biomedica_00748866.jpg caption=In the HCS assessment (Table 1), Normal Human Bronchial Epithelial (NHBE) cells were exposed in a concentration-dependent manner to 34 individual flavor ingredients and to non-flavored (base) matrix for either 4 h or 24 h (30 min for the NF-kB translocation endpoint.) (Gonzalez-Suarez et al., 2016; Marescotti et al., 2016) Results are shown in "ftox-04-878976-g004" ="fig">Figure 4 in three heatmaps which grouped these flavor ingredients based on minimal effective concentration (MEC) profile similarities and the Tox or Phenotypic Score (ratio of MEC base solution/MEC flavored solution) is shown in in three heatmaps which grouped these flavor ingredients based on minimal effective concentration (MEC) profile similarities and the Tox or Phenotypic Score (ratio of MEC base solution/MEC flavored solution) is shown in Table 2. Flavor ingredients in heatmap “A” had the lowest impact for most of the HCS endpoints tested, which also fits with their lower Tox Score as well as with their lower ph source=biomedica enhanced_caption=O: In the HCS assessment (Table 1), Normal Human Bronchial Epithelial (NHBE) cells were exposed in a concentration-dependent manner to 34 individual flavor ingredients and to non-flavored (base) matrix for either 4 h or 24 h (30 min for the NF-kB translocation endpoint.) (Gonzalez-Suarez et al., 2016; Marescotti et al., 2016) Results are shown in "ftox-04-878976-g004" ="fig">Figure 4 in three heatmaps which grouped these flavor ingredients based on minimal effective concentration (MEC) profile similarities and the Tox or Phenotypic Score (ratio of MEC base solution/MEC flavored solution) is shown in in three heatmaps which grouped these flavor ingredients based on minimal effective concentration (MEC) profile similarities and the Tox or Phenotypic Score (ratio of MEC base solution/MEC flavored solution) is shown in Table 2. Flavor ingredients in heatmap “A” had the lowest impact for most of the HCS endpoints tested, which also fits with their lower Tox Score as well as with their lower think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=67yo Asian female
|
file_name=biomedica_00580749.jpg caption=Eresus contains 23 recognized species group names (including 6 subspecies) from the Mediterranean and temperate latitudes of Europe and Asia. We examined specimens of several species representing the two major morphological groups within the genus. Our first exemplar, Eresus walckenaeri, is a cohesive species, based on both morphological and molecular data (Johannesen et al. 2005). Our specimens were from Bulgaria and Greece (Kresna, Bulgaria, MR; Pieria, Greece, MR020, MR; Lakonia, Greece, ZMUC 00012903, ZMUC). The primary types of Eresus walckenaeri are probably lost, but the original description and drawings, and our use in part of nearly topotypic material, allow us to identify this species with confidence. The second major group within the genus is a complex of closely related species including Eresus kollari (including the junior synonyms Eresus cinnaberinus and Eresus niger) and Eresus sandaliatus (Martini & Goeze, 1778); we refer to this assemblage collectively as the Eresus sa source=biomedica enhanced_caption=O: Eresus contains 23 recognized species group names (including 6 subspecies) from the Mediterranean and temperate latitudes of Europe and Asia. We examined specimens of several species representing the two major morphological groups within the genus. Our first exemplar, Eresus walckenaeri, is a cohesive species, based on both morphological and molecular data (Johannesen et al. 2005). Our specimens were from Bulgaria and Greece (Kresna, Bulgaria, MR; Pieria, Greece, MR020, MR; Lakonia, Greece, ZMUC 00012903, ZMUC). The primary types of Eresus walckenaeri are probably lost, but the original description and drawings, and our use in part of nearly topotypic material, allow us to identify this species with confidence. The second major group within the genus is a complex of closely related species including Eresus kollari (including the junior synonyms Eresus cinnaberinus and Eresus niger) and Eresus sandaliatus (Martini & Goeze, 1778); we refer to this assemblage collectively as the Eresus think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=36yo Indigenous female
|
file_name=biomedica_00018549.jpg caption=We examined whether PIP5Kγ catalytic activity is involved in its regulation of LATS1 and YAP by comparing the effects of green fluorescent protein (GFP)-tagged kinase-dead (KD) PIP5Kγ90 (K407N, K408N) and wild-type (WT) forms. The indicated lysine residues are located in the kinase homology domain of the type I PIP5K family and mediate their catalytic function [30,31]. Unlike GFP-PIP5Kγ90 WT overexpression, GFP-PIP5Kγ90 KD overexpression did not effectively increase the phosphorylation levels of LATS1 and YAP ( "ijms-24-14786-g002" ="fig">Figure 2 A and A and Figure S1D). GFP-PIP5Kγ90 KD was less effective in downregulating CTGF, CYR61, and ANKRD1 induction than GFP-PIP5Kγ90 WT ( "ijms-24-14786-g002" ="fig">Figure 2 B). In accordance with these results, GFP-PIP5Kγ90 WT, but not the KD mutant, prevented the nuclear enrichment of YAP (B). In accordance with these results, GFP-PIP5Kγ90 WT, but not the KD mutant, prevented the nuclear enrichment of YAP ( "ijms-24-14786-g002" ="fig">Figure source=biomedica enhanced_caption=O: We examined whether PIP5Kγ catalytic activity is involved in its regulation of LATS1 and YAP by comparing the effects of green fluorescent protein (GFP)-tagged kinase-dead (KD) PIP5Kγ90 (K407N, K408N) and wild-type (WT) forms. The indicated lysine residues are located in the kinase homology domain of the type I PIP5K family and mediate their catalytic function [30,31]. Unlike GFP-PIP5Kγ90 WT overexpression, GFP-PIP5Kγ90 KD overexpression did not effectively increase the phosphorylation levels of LATS1 and YAP ( "ijms-24-14786-g002" ="fig">Figure 2 A and A and Figure S1D). GFP-PIP5Kγ90 KD was less effective in downregulating CTGF, CYR61, and ANKRD1 induction than GFP-PIP5Kγ90 WT ( "ijms-24-14786-g002" ="fig">Figure 2 B). In accordance with these results, GFP-PIP5Kγ90 WT, but not the KD mutant, prevented the nuclear enrichment of YAP (B). In accordance with these results, GFP-PIP5Kγ90 WT, but not the KD mutant, prevented the nuclear enrichment of YAP ( "ijms-24-14786-g002" ="fig">Figu think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=52yo Indigenous male
|
file_name=biomedica_00032321.jpg caption=Upon closer inspection of the collected images, we observed that they exhibit the characteristics of directional haze S^k(x)∗G^j(k), atmospheric light L(x), and attenuation of the original image signal R(x) (see "jimaging-09-00153-g004" ="fig">Figure 4 for details). Furthermore, we observed that the rendered scenes also exhibit a reduction in shadow contrast due to the presence of haze. These characteristic changes are often overlooked in conventional image dehazing. However, with the guidance of the three-dimensional scattering formula, achieving these characteristic changes becomes much easier. for details). Furthermore, we observed that the rendered scenes also exhibit a reduction in shadow contrast due to the presence of haze. These characteristic changes are often overlooked in conventional image dehazing. However, with the guidance of the three-dimensional scattering formula, achieving these characteristic changes becomes much easier. Next, we improved the structure of the loss u source=biomedica enhanced_caption=O: Upon closer inspection of the collected images, we observed that they exhibit the characteristics of directional haze S^k(x)∗G^j(k), atmospheric light L(x), and attenuation of the original image signal R(x) (see "jimaging-09-00153-g004" ="fig">Figure 4 for details). Furthermore, we observed that the rendered scenes also exhibit a reduction in shadow contrast due to the presence of haze. These characteristic changes are often overlooked in conventional image dehazing. However, with the guidance of the three-dimensional scattering formula, achieving these characteristic changes becomes much easier. for details). Furthermore, we observed that the rendered scenes also exhibit a reduction in shadow contrast due to the presence of haze. These characteristic changes are often overlooked in conventional image dehazing. However, with the guidance of the three-dimensional scattering formula, achieving these characteristic changes becomes much easier. Next, we improved the structure of the los think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=48yo Middle Eastern male
|
file_name=biomedica_00312783.jpg caption=To determine whether the method could be readily applied to human-derived cells, we also seeded decellularized scaffolds with cardiomyocytes derived from human embryonic cells (hESC-CM) or hiPSC-CMs ( ="fig" "srep32068-f7">Fig. 7a ). Using standard media conditions, hESC-CMs produced beating scaffolds with measurable intracellular Ca). Using standard media conditions, hESC-CMs produced beating scaffolds with measurable intracellular Ca2+ transients and maximum twitch stress of 1.7 mN/mm2 at day 16 (n = 3) ( ="fig" "srep32068-f7">Fig. 7b ). Scaffolds seeded with hiPSC-CM (obtained from a healthy donor) were cultured in media containing thyroid hormone, IGF-1, and the glucocorticoid analog dexamethasone, factors recently shown to promote cardiomyocyte maturation). Scaffolds seeded with hiPSC-CM (obtained from a healthy donor) were cultured in media containing thyroid hormone, IGF-1, and the glucocorticoid analog dexamethasone, factors recently shown to promote cardiomyocyte maturation22. source=biomedica enhanced_caption=O: To determine whether the method could be readily applied to human-derived cells, we also seeded decellularized scaffolds with cardiomyocytes derived from human embryonic cells (hESC-CM) or hiPSC-CMs ( ="fig" "srep32068-f7">Fig. 7a ). Using standard media conditions, hESC-CMs produced beating scaffolds with measurable intracellular Ca). Using standard media conditions, hESC-CMs produced beating scaffolds with measurable intracellular Ca2+ transients and maximum twitch stress of 1.7 mN/mm2 at day 16 (n = 3) ( ="fig" "srep32068-f7">Fig. 7b ). Scaffolds seeded with hiPSC-CM (obtained from a healthy donor) were cultured in media containing thyroid hormone, IGF-1, and the glucocorticoid analog dexamethasone, factors recently shown to promote cardiomyocyte maturation). Scaffolds seeded with hiPSC-CM (obtained from a healthy donor) were cultured in media containing thyroid hormone, IGF-1, and the glucocorticoid analog dexamethasone, factors recently shown to promote cardiomyocyte maturation think=<think>Visual findings present in image → Clinical correlation needed → ICD Z13.9 assigned → Moderate uncertainty due to limited context</think> icd_code=Z13.9 uncertainty=medium modality=multi-modal demographic=36yo Indigenous female
|
file_name=biomedica_00674118.jpg caption=The hemodynamic parameters of cardiac function have been summarized in "IJMS-47-367-g001" ="fig">figure 1 . The values of the LVSP (P=0.002), LVDP (P<0.001), +dp/dt (P=0.014), and RPP (P=0.003) in the BDL group were significantly higher than those of the Sham-operated group (figures . The values of the LVSP (P=0.002), LVDP (P<0.001), +dp/dt (P=0.014), and RPP (P=0.003) in the BDL group were significantly higher than those of the Sham-operated group (figures "IJMS-47-367-g001" ="fig">1 a-c, f ). In comparison to the sham-operated group, the LVSP (P=0.021), LVDP (P=0.006), and +dp/dt (P=0.020) were still higher in the BDL+SE300 group, so that there was no significant difference between the values and the BDL ones. All aforementioned parameters have been restored to the normal level in the BDL+SE600 group. The same pattern was also observed for the LVSP (P=0.052), LVDP (P=0.006), and +dp/dt (P=0.020) of SE600, when compared to those of BDL (figures ). In comparison to the sham-operated source=biomedica enhanced_caption=O: The hemodynamic parameters of cardiac function have been summarized in "IJMS-47-367-g001" ="fig">figure 1 . The values of the LVSP (P=0.002), LVDP (P<0.001), +dp/dt (P=0.014), and RPP (P=0.003) in the BDL group were significantly higher than those of the Sham-operated group (figures . The values of the LVSP (P=0.002), LVDP (P<0.001), +dp/dt (P=0.014), and RPP (P=0.003) in the BDL group were significantly higher than those of the Sham-operated group (figures "IJMS-47-367-g001" ="fig">1 a-c, f ). In comparison to the sham-operated group, the LVSP (P=0.021), LVDP (P=0.006), and +dp/dt (P=0.020) were still higher in the BDL+SE300 group, so that there was no significant difference between the values and the BDL ones. All aforementioned parameters have been restored to the normal level in the BDL+SE600 group. The same pattern was also observed for the LVSP (P=0.052), LVDP (P=0.006), and +dp/dt (P=0.020) of SE600, when compared to those of BDL (figures ). In comparison to the sham-opera think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=42yo Black female
|
file_name=biomedica_00164625.jpg caption=Continuous timeseries of CO, CO2, and MCE are shown in "nihms-1539427-f0002" ="fig">Figure 2 , with raw data provided in the Supplemental Information (, with raw data provided in the Supplemental Information (Tables S1–S4). CO and CO2 were measured both in canisters and with continuous instruments, with linear regressions showing (4)[COcanister]=0.82⋅[COcontinuous]+1.24ppm(r2=0.981) and (5)[CO2,canister]=1.09⋅[CO2,continuous]−18.69ppm(r2=0.979). source=biomedica enhanced_caption=O: Continuous timeseries of CO, CO2, and MCE are shown in "nihms-1539427-f0002" ="fig">Figure 2 , with raw data provided in the Supplemental Information (, with raw data provided in the Supplemental Information (Tables S1–S4). CO and CO2 were measured both in canisters and with continuous instruments, with linear regressions showing (4)[COcanister]=0.82⋅[COcontinuous]+1.24ppm(r2=0.981) and (5)[CO2,canister]=1.09⋅[CO2,continuous]−18.69ppm(r2=0.979). A: Clinical findings require correlation. P: Further evaluation recommended. think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=55yo Hispanic male
|
file_name=biomedica_00542058.jpg caption=Most of the instances included travel to, residence in, or interaction with tourists from the Middle East. However, certain cases have also been reported in North America, Asia, Europe, and Africa, among other regions of the world (Fig. "ms9-86-4668-g001" ="fig">1 ). Many of these infections were connected to visitors or medical professionals who had come into contact with MERS-CoV patients or camels in middle east.). Many of these infections were connected to visitors or medical professionals who had come into contact with MERS-CoV patients or camels in middle east. source=biomedica enhanced_caption=O: Most of the instances included travel to, residence in, or interaction with tourists from the Middle East. However, certain cases have also been reported in North America, Asia, Europe, and Africa, among other regions of the world (Fig. "ms9-86-4668-g001" ="fig">1 ). Many of these infections were connected to visitors or medical professionals who had come into contact with MERS-CoV patients or camels in middle east.). Many of these infections were connected to visitors or medical professionals who had come into contact with MERS-CoV patients or camels in middle east. A: Clinical findings require correlation. P: Further evaluation recommended. think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=25yo White male
|
file_name=biomedica_00750341.jpg caption=The metabolite profiles of xylem sap of tobacco cultivars Yunyan87 and K326 were determined by untargeted metabolome analysis at 7 days post R. pseudosolanacearum inoculation (Supplementary Figure S1). The results displayed that R. pseudosolanacearum infection changes the chemical composition of tobacco xylem sap ( "fpls-12-780429-g002" ="fig">Figure 2 ). Principal component analysis (PCA) of all samples indicated that the susceptible tobacco cultivar Yunyan87 showed dramatic metabolite changes after ). Principal component analysis (PCA) of all samples indicated that the susceptible tobacco cultivar Yunyan87 showed dramatic metabolite changes after R. pseudosolanacearum infection, while the quantitatively resistant variety K326 showed few metabolite differences (Supplementary Figure S1). GC-MS analysis of the xylem sap samples detected 88 known compounds, including 48 metabolites identified as differentially concentrated ( "fpls-12-780429-g002" ="fig">Figure 2 ). Interestingly, samples source=biomedica enhanced_caption=O: The metabolite profiles of xylem sap of tobacco cultivars Yunyan87 and K326 were determined by untargeted metabolome analysis at 7 days post R. pseudosolanacearum inoculation (Supplementary Figure S1). The results displayed that R. pseudosolanacearum infection changes the chemical composition of tobacco xylem sap ( "fpls-12-780429-g002" ="fig">Figure 2 ). Principal component analysis (PCA) of all samples indicated that the susceptible tobacco cultivar Yunyan87 showed dramatic metabolite changes after ). Principal component analysis (PCA) of all samples indicated that the susceptible tobacco cultivar Yunyan87 showed dramatic metabolite changes after R. pseudosolanacearum infection, while the quantitatively resistant variety K326 showed few metabolite differences (Supplementary Figure S1). GC-MS analysis of the xylem sap samples detected 88 known compounds, including 48 metabolites identified as differentially concentrated ( "fpls-12-780429-g002" ="fig">Figure 2 ). Interestingly, samp think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=28yo South Asian female
|
file_name=biomedica_00177179.jpg caption=(A) Effects of nitrogen content and NPy/NQ ratio on water capacity of N-CNTs; (B) N2 pore volume and acetone capacity of the CNTs and N-CNTs. (A) Reprinted from [53], Copyright 2018, with permission of American Chemical Society. (B) Reprinted from [54], Copyright 2021 by the authors. source=biomedica enhanced_caption=O: (A) Effects of nitrogen content and NPy/NQ ratio on water capacity of N-CNTs; (B) N2 pore volume and acetone capacity of the CNTs and N-CNTs. (A) Reprinted from [53], Copyright 2018, with permission of American Chemical Society. (B) Reprinted from [54], Copyright 2021 by the authors. A: Clinical findings require correlation. P: Further evaluation recommended. think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=67yo Asian female
|
file_name=biomedica_00027791.jpg caption=We based our depth sensor initial-calibration method (DDC) on the D-KHT method proposed by Vera et al. [31]. They also calculated the gradient of the depth image using Equation (1) and PCA. However, they computed recursively and in block units using Quadtree instead of incorporating all pixel calculations as we proposed in Section 2.2. Their method, using Quadtree, can calculate faster than the method that uses all pixels. They used Quadtree’s recursive division criterion (st) as the square root of the third eigenvalue of PCA (i.e., the standard deviation of the distance between the plane and the point). ="fig" "sensors-19-04581-g003">Figure 3 a shows the result of calculating the gradient of a shows the result of calculating the gradient of Qi as Ni = (Ni,x, Ni,y, Ni,z) of the image ( ="fig" "sensors-19-04581-g001">Figure 1 b), where the b), where the ith Quadtree is Qi, st = 2 cm, and color coding is based on Equation (3). Red and blue in ="fig" "sensors-19-04581-g003">Figure 3 b sho source=biomedica enhanced_caption=O: We based our depth sensor initial-calibration method (DDC) on the D-KHT method proposed by Vera et al. [31]. They also calculated the gradient of the depth image using Equation (1) and PCA. However, they computed recursively and in block units using Quadtree instead of incorporating all pixel calculations as we proposed in Section 2.2. Their method, using Quadtree, can calculate faster than the method that uses all pixels. They used Quadtree’s recursive division criterion (st) as the square root of the third eigenvalue of PCA (i.e., the standard deviation of the distance between the plane and the point). ="fig" "sensors-19-04581-g003">Figure 3 a shows the result of calculating the gradient of a shows the result of calculating the gradient of Qi as Ni = (Ni,x, Ni,y, Ni,z) of the image ( ="fig" "sensors-19-04581-g001">Figure 1 b), where the b), where the ith Quadtree is Qi, st = 2 cm, and color coding is based on Equation (3). Red and blue in ="fig" "sensors-19-04581-g003">Figure 3 b think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=55yo Hispanic male
|
file_name=biomedica_00656268.jpg caption=With the lists of female and male differentially expressed genes at hand, a gene ontology (GO) analysis was performed, and Figs ="fig" "pntd.0006873.g010">10 and and ="fig" "pntd.0006873.g011">11 show the top 20 GO enriched terms for downregulated genes in female ( show the top 20 GO enriched terms for downregulated genes in female ( ="fig" "pntd.0006873.g010">Fig 10A ) and male worms () and male worms ( ="fig" "pntd.0006873.g010">Fig 10B ) as well as the enriched terms for upregulated genes in males () as well as the enriched terms for upregulated genes in males ( ="fig" "pntd.0006873.g011">Fig 11 ). No significantly enriched GO terms (FDR ≤ 0.05) were detected among the upregulated genes in females. GSK343 caused alterations in genes related to various metabolic pathways, which are different between females and males, as expected from the minimal overlap of DEGs (). No significantly enriched GO terms (FDR ≤ 0.05) were detected among the upregulated genes in females. GSK343 caused alt source=biomedica enhanced_caption=O: With the lists of female and male differentially expressed genes at hand, a gene ontology (GO) analysis was performed, and Figs ="fig" "pntd.0006873.g010">10 and and ="fig" "pntd.0006873.g011">11 show the top 20 GO enriched terms for downregulated genes in female ( show the top 20 GO enriched terms for downregulated genes in female ( ="fig" "pntd.0006873.g010">Fig 10A ) and male worms () and male worms ( ="fig" "pntd.0006873.g010">Fig 10B ) as well as the enriched terms for upregulated genes in males () as well as the enriched terms for upregulated genes in males ( ="fig" "pntd.0006873.g011">Fig 11 ). No significantly enriched GO terms (FDR ≤ 0.05) were detected among the upregulated genes in females. GSK343 caused alterations in genes related to various metabolic pathways, which are different between females and males, as expected from the minimal overlap of DEGs (). No significantly enriched GO terms (FDR ≤ 0.05) were detected among the upregulated genes in females. GSK343 caused think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=32yo Hispanic female
|
file_name=biomedica_00393835.jpg caption=In addition, obese patients presented significantly higher skin AGEs accumulation compared to healthy controls (1.2 ± 0.21 vs. 1.1 ± 0.21, p = 0.03) (Fig. "41598_2023_39566_Fig3_HTML" ="fig">3 ).).Figure 3Increased AGEs skin accumulation in obese children. The unpaired t-test found that patients with obesity presented significantly higher skin AGEs accumulation compared to healthy controls. Data are expressed as mean 95% CI. Abbreviations: sAF, skin autofluorescence. source=biomedica enhanced_caption=O: In addition, obese patients presented significantly higher skin AGEs accumulation compared to healthy controls (1.2 ± 0.21 vs. 1.1 ± 0.21, p = 0.03) (Fig. "41598_2023_39566_Fig3_HTML" ="fig">3 ).).Figure 3Increased AGEs skin accumulation in obese children. The unpaired t-test found that patients with obesity presented significantly higher skin AGEs accumulation compared to healthy controls. Data are expressed as mean 95% CI. Abbreviations: sAF, skin autofluorescence. A: Clinical findings require correlation. P: Further evaluation recommended. think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=71yo Asian male
|
file_name=biomedica_00309055.jpg caption=The active component-disease-target (C-D-T) network was constructed in Cytoscape 3.9.1. The result was shown in Fig. "41598_2024_61011_Fig3_HTML" ="fig">3 . The network contains 502 nodes and 2246 edges. The analyses showed that A17 (quercetin, degree: 136), A11 (kaempferol, degree: 58), A13 (luteolin, degree: 56), CZ1 (wogonin, degree: 44), DS54 (tanshinone iia, degree: 38) and HJ1(baicalein, degree: 34) had the highest degrees. These components may play crucial roles on JLD against T2DM.. The network contains 502 nodes and 2246 edges. The analyses showed that A17 (quercetin, degree: 136), A11 (kaempferol, degree: 58), A13 (luteolin, degree: 56), CZ1 (wogonin, degree: 44), DS54 (tanshinone iia, degree: 38) and HJ1(baicalein, degree: 34) had the highest degrees. These components may play crucial roles on JLD against T2DM.Figure 3Network of active component-disease-target. Orange ovals represent the 317 common targets of JLD and T2DM targets. Green diamonds represent the disease related source=biomedica enhanced_caption=O: The active component-disease-target (C-D-T) network was constructed in Cytoscape 3.9.1. The result was shown in Fig. "41598_2024_61011_Fig3_HTML" ="fig">3 . The network contains 502 nodes and 2246 edges. The analyses showed that A17 (quercetin, degree: 136), A11 (kaempferol, degree: 58), A13 (luteolin, degree: 56), CZ1 (wogonin, degree: 44), DS54 (tanshinone iia, degree: 38) and HJ1(baicalein, degree: 34) had the highest degrees. These components may play crucial roles on JLD against T2DM.. The network contains 502 nodes and 2246 edges. The analyses showed that A17 (quercetin, degree: 136), A11 (kaempferol, degree: 58), A13 (luteolin, degree: 56), CZ1 (wogonin, degree: 44), DS54 (tanshinone iia, degree: 38) and HJ1(baicalein, degree: 34) had the highest degrees. These components may play crucial roles on JLD against T2DM.Figure 3Network of active component-disease-target. Orange ovals represent the 317 common targets of JLD and T2DM targets. Green diamonds represent the disease rela think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=39yo Middle Eastern female
|
file_name=biomedica_00165428.jpg caption="sensors-23-08161-g017" ="fig">Figure 17 showcases data in the frequency domain. It can be seen from showcases data in the frequency domain. It can be seen from "sensors-23-08161-g017" ="fig">Figure 17 a,c that the FFT spectra are marred by noise, making it challenging to discern the transverse vibration modes. It is also worth reporting such data along with possible reasons and recommendations for future work. Nonetheless, when comparing the two spectra, there are some observations: the frequency peak at 0.114 Hz from the camera data aligns with the 0.0993 Hz frequency peak from the accelerometer, reflecting a 14.8% difference. It is also worth highlighting that the two frequencies between 0 Hz and 0.045 Hz evident in the peaks from the camera data in a,c that the FFT spectra are marred by noise, making it challenging to discern the transverse vibration modes. It is also worth reporting such data along with possible reasons and recommendations for future work. Nonetheless, when compar source=biomedica enhanced_caption=O: "sensors-23-08161-g017" ="fig">Figure 17 showcases data in the frequency domain. It can be seen from showcases data in the frequency domain. It can be seen from "sensors-23-08161-g017" ="fig">Figure 17 a,c that the FFT spectra are marred by noise, making it challenging to discern the transverse vibration modes. It is also worth reporting such data along with possible reasons and recommendations for future work. Nonetheless, when comparing the two spectra, there are some observations: the frequency peak at 0.114 Hz from the camera data aligns with the 0.0993 Hz frequency peak from the accelerometer, reflecting a 14.8% difference. It is also worth highlighting that the two frequencies between 0 Hz and 0.045 Hz evident in the peaks from the camera data in a,c that the FFT spectra are marred by noise, making it challenging to discern the transverse vibration modes. It is also worth reporting such data along with possible reasons and recommendations for future work. Nonetheless, when com think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=58yo White female
|
file_name=biomedica_00000234.jpg caption=Cytokines are pluripotent proteins that play key roles in the induction and maintenance of pain [25]. In particular, monocyte chemoattractant protein (MCP)-1 increases the excitability of nociceptive neurons in chronically pathological dorsal root ganglia [25] and interleukin (IL)-6 plays critical roles in the development of pathological pain [26]; therefore, we wanted to analyze the MCP-1 and IL-6 expressions in the spinal cord after PRF stimulation. As shown in "ijms-22-11865-g003" ="fig">Figure 3 A,B, 7 days after stimulation of the nerve with PRF 30–60 V, A,B, 7 days after stimulation of the nerve with PRF 30–60 V, MCP-1 expression increased in a voltage-dependent manner, and after 28 days of PRF stimulation with 30 V and 45 V, the expression of MCP-1 returned to the baseline; however, rats stimulated with 60 V of PRF still had a high production of MCP-1 in the lumbar dorsal horn on Day 28. In contrast, for IL-6, PRF stimulation at 45 V only slightly increased on Day 7; if the volt source=biomedica enhanced_caption=O: Cytokines are pluripotent proteins that play key roles in the induction and maintenance of pain [25]. In particular, monocyte chemoattractant protein (MCP)-1 increases the excitability of nociceptive neurons in chronically pathological dorsal root ganglia [25] and interleukin (IL)-6 plays critical roles in the development of pathological pain [26]; therefore, we wanted to analyze the MCP-1 and IL-6 expressions in the spinal cord after PRF stimulation. As shown in "ijms-22-11865-g003" ="fig">Figure 3 A,B, 7 days after stimulation of the nerve with PRF 30–60 V, A,B, 7 days after stimulation of the nerve with PRF 30–60 V, MCP-1 expression increased in a voltage-dependent manner, and after 28 days of PRF stimulation with 30 V and 45 V, the expression of MCP-1 returned to the baseline; however, rats stimulated with 60 V of PRF still had a high production of MCP-1 in the lumbar dorsal horn on Day 28. In contrast, for IL-6, PRF stimulation at 45 V only slightly increased on Day 7; if the v think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=32yo Hispanic female
|
file_name=biomedica_00392642.jpg caption=Romidepsin is reduced intracellularly to yield the active form of the drug that has two thiol groups, one of which coordinates with a zinc ion to inhibit HDACs [10]. We previously found that when cells that overexpress TMT1A are treated with romidepsin, dimethylated romidepsin can be detected in the culture medium [9]. To determine if TMT1A homologs from different species could also methylate romidepsin, empty vector cells and cells expressing the TMT1A homologs were incubated with 10 μM romidepsin for 24 h and both unmodified and dimethylated romidepsin were measured by LC-MS/MS. Cells expressing zebrafish or chicken TMT1A had the lowest proportion of dimethylated romidepsin relative to total romidepsin, while cells expressing the mouse or rat isoforms had levels comparable to cells expressing human TMT1A ( "nihpp-2023.11.17.567538v1-f0005" ="fig">Fig 5 ). These results are in accordance with cytotoxicity assay data, which show that cells expressing zebrafish or chicken TMT1A were les source=biomedica enhanced_caption=O: Romidepsin is reduced intracellularly to yield the active form of the drug that has two thiol groups, one of which coordinates with a zinc ion to inhibit HDACs [10]. We previously found that when cells that overexpress TMT1A are treated with romidepsin, dimethylated romidepsin can be detected in the culture medium [9]. To determine if TMT1A homologs from different species could also methylate romidepsin, empty vector cells and cells expressing the TMT1A homologs were incubated with 10 μM romidepsin for 24 h and both unmodified and dimethylated romidepsin were measured by LC-MS/MS. Cells expressing zebrafish or chicken TMT1A had the lowest proportion of dimethylated romidepsin relative to total romidepsin, while cells expressing the mouse or rat isoforms had levels comparable to cells expressing human TMT1A ( "nihpp-2023.11.17.567538v1-f0005" ="fig">Fig 5 ). These results are in accordance with cytotoxicity assay data, which show that cells expressing zebrafish or chicken TMT1A were think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=55yo Hispanic male
|
file_name=biomedica_00681697.jpg caption=The pFAK expression (H-score >0) was seen in 77% of DSRCT (10/13), 25% of ES (17/68), 70% of ARMS (14/20), and 26% of ERMS tissues (10/39). High pFAK expression (H-score >100) was seen in 38% of DSRCT (5/13), 3% of ES (2/68), 15% of ARMS (3/20), and 13% of ERMS (5/39) ( "SARCOMA2022-3089424.001" ="fig">Figure 1(a) ).). Baseline Src expression was seen in 100% of DSRCT (13/13), 88% of ES (56/64), 95% of ARMS (19/20), and 86% of ERMS (32/37). pSrc expression (H-score >0) was seen in 83% of DSRCT (10/12), 39% of ES (25/64), 76% of ARMS (16/21), and 35% of ERMS tissues (13/37). High pSrc expression (H-score >100) was seen in 58% of DRSCT (7/12), 8% of ES (5/64), 38% of ARMS (8/21), and 19% of ERMS (7/37) ( "SARCOMA2022-3089424.001" ="fig">Figure 1(b) ).). Concurrent pFAK and pSrc expressions could be assessed in 12 DSRCT, 62 ES, 20 ARMS, and 36 ERMS tumor samples. Concurrent pFAKpos and pSrcpos expressions were seen in 8/12 (67%) DSRCT, 4/62 (6%) ES, 7/20 (35%) ARMS, and 7/36 (19%) ERMS tu source=biomedica enhanced_caption=O: The pFAK expression (H-score >0) was seen in 77% of DSRCT (10/13), 25% of ES (17/68), 70% of ARMS (14/20), and 26% of ERMS tissues (10/39). High pFAK expression (H-score >100) was seen in 38% of DSRCT (5/13), 3% of ES (2/68), 15% of ARMS (3/20), and 13% of ERMS (5/39) ( "SARCOMA2022-3089424.001" ="fig">Figure 1(a) ).). Baseline Src expression was seen in 100% of DSRCT (13/13), 88% of ES (56/64), 95% of ARMS (19/20), and 86% of ERMS (32/37). pSrc expression (H-score >0) was seen in 83% of DSRCT (10/12), 39% of ES (25/64), 76% of ARMS (16/21), and 35% of ERMS tissues (13/37). High pSrc expression (H-score >100) was seen in 58% of DRSCT (7/12), 8% of ES (5/64), 38% of ARMS (8/21), and 19% of ERMS (7/37) ( "SARCOMA2022-3089424.001" ="fig">Figure 1(b) ).). Concurrent pFAK and pSrc expressions could be assessed in 12 DSRCT, 62 ES, 20 ARMS, and 36 ERMS tumor samples. Concurrent pFAKpos and pSrcpos expressions were seen in 8/12 (67%) DSRCT, 4/62 (6%) ES, 7/20 (35%) ARMS, and 7/36 (19%) ERMS think=<think>Visual findings present in image → Clinical correlation needed → ICD D49.9 assigned → Moderate uncertainty due to limited context</think> icd_code=D49.9 uncertainty=medium modality=multi-modal demographic=39yo Middle Eastern female
|
file_name=biomedica_00757667.jpg caption=The abundance of microbial communities in the cecum of the two animal groups was analyzed at the phylum and genus levels. From "fmicb-15-1368736-g008" ="fig">Figure 8A , it is apparent that at the phylum level, , it is apparent that at the phylum level, Bacteroidetes, Firmicutes, Proteobacteria, Actinobacteria, Deferribacteres, and Epsilonbacteraeota are the predominant taxa in the cecum. Specifically, the abundance of Firmicutes (47.30%) was observed to be the highest in the CON group, while Bacteroidetes (70.82%) exhibited the highest abundance in the CSB group. In comparison to the CON group, the CSB group displayed a significant increase in the abundance of Bacteroidetes (p < 0.01) and a notable decrease in the abundance of Proteobacteria, Deferribacteres, and Epsilonbacteraeota (p < 0.05), with no significant impact observed on other phylum-level microbial communities. Additionally, from "fmicb-15-1368736-g008" ="fig">Figure 8B , at the genus level, , at the genus level, Bacteroid source=biomedica enhanced_caption=O: The abundance of microbial communities in the cecum of the two animal groups was analyzed at the phylum and genus levels. From "fmicb-15-1368736-g008" ="fig">Figure 8A , it is apparent that at the phylum level, , it is apparent that at the phylum level, Bacteroidetes, Firmicutes, Proteobacteria, Actinobacteria, Deferribacteres, and Epsilonbacteraeota are the predominant taxa in the cecum. Specifically, the abundance of Firmicutes (47.30%) was observed to be the highest in the CON group, while Bacteroidetes (70.82%) exhibited the highest abundance in the CSB group. In comparison to the CON group, the CSB group displayed a significant increase in the abundance of Bacteroidetes (p < 0.01) and a notable decrease in the abundance of Proteobacteria, Deferribacteres, and Epsilonbacteraeota (p < 0.05), with no significant impact observed on other phylum-level microbial communities. Additionally, from "fmicb-15-1368736-g008" ="fig">Figure 8B , at the genus level, , at the genus level, Bacter think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=32yo Hispanic female
|
file_name=biomedica_00310293.jpg caption=Gross credit exposure and gross market values, 1998–2018. See stats.bis.org; BIS derivatives statistics, OTC derivatives outstanding for all counterparties and risk categories on a net-net basis. source=biomedica enhanced_caption=O: Gross credit exposure and gross market values, 1998–2018. See stats.bis.org; BIS derivatives statistics, OTC derivatives outstanding for all counterparties and risk categories on a net-net basis. A: Clinical findings require correlation. P: Further evaluation recommended. think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=71yo Asian male
|
file_name=biomedica_00402331.jpg caption=The transformer network was proposed in Vaswani et al. [20]. It is composed of several identical layers. Each layer was made up of two sub-layers, the multi-head self-attention mechanism and the fully connected feed-forward network, as shown in ="fig" "sensors-21-01751-g003">Figure 3 . A residual connection followed by layer normalization is employed in each sub-layer. So, the output of each sub-layer can be defined as . A residual connection followed by layer normalization is employed in each sub-layer. So, the output of each sub-layer can be defined as LayerNorm(x + SubLayer(x)), where SubLayer(x) denotes the function implemented by the sub-layer. The multi-head self-attention is defined as:(3)MultiHead(Q,K,V)=concathead1,⋯,headhWO, where headi= Attention QWiQ,KWiK,VWiV,WiQ∈Rdmodel×dq, WiK∈Rdmodel×dk, WiV∈Rdmodel×dv, and WO∈Rh×dv×dmodel are parameter matrices. The attention is formulated as:(4)Attention(Q,K,V)=softmaxQKTdkV, where Q, K of dimension dk, and V of dimension dv are three source=biomedica enhanced_caption=O: The transformer network was proposed in Vaswani et al. [20]. It is composed of several identical layers. Each layer was made up of two sub-layers, the multi-head self-attention mechanism and the fully connected feed-forward network, as shown in ="fig" "sensors-21-01751-g003">Figure 3 . A residual connection followed by layer normalization is employed in each sub-layer. So, the output of each sub-layer can be defined as . A residual connection followed by layer normalization is employed in each sub-layer. So, the output of each sub-layer can be defined as LayerNorm(x + SubLayer(x)), where SubLayer(x) denotes the function implemented by the sub-layer. The multi-head self-attention is defined as:(3)MultiHead(Q,K,V)=concathead1,⋯,headhWO, where headi= Attention QWiQ,KWiK,VWiV,WiQ∈Rdmodel×dq, WiK∈Rdmodel×dk, WiV∈Rdmodel×dv, and WO∈Rh×dv×dmodel are parameter matrices. The attention is formulated as:(4)Attention(Q,K,V)=softmaxQKTdkV, where Q, K of dimension dk, and V of dimension dv are th think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=67yo Asian female
|
file_name=biomedica_00384669.jpg caption="polymers-14-03679-g009" ="fig">Figure 9 shows the inter-laminar shear strength (ILSS) of the dry and wet hybrid composites. Regardless of the exposure duration, similar ILSS behaviour can be observed for wet specimens with different amounts of graphene. Wet composites with 0.5% graphene failed at the highest ILSS strength of 15.9 MPa for 1000 h, which is 11% lower than the dry composites. This is the same mechanism observed in flexural strength, where there is a good filler distribution in the matrix. However, the highest reduction in wet ILSS strength was observed for specimens with 1% graphene, which was 20%, 23% and 25% lower than that of the dry ILSS strength for 1000, 2000 and 3000 h, respectively, as a result of the plasticization effect at the flax fibre/epoxy matrix interface from higher moisture absorption, which has been demonstrated at lower Tg values. This effect could be more pronounced by the agglomeration of graphene nanoparticles as the epoxy becomes more viscous after source=biomedica enhanced_caption=O: "polymers-14-03679-g009" ="fig">Figure 9 shows the inter-laminar shear strength (ILSS) of the dry and wet hybrid composites. Regardless of the exposure duration, similar ILSS behaviour can be observed for wet specimens with different amounts of graphene. Wet composites with 0.5% graphene failed at the highest ILSS strength of 15.9 MPa for 1000 h, which is 11% lower than the dry composites. This is the same mechanism observed in flexural strength, where there is a good filler distribution in the matrix. However, the highest reduction in wet ILSS strength was observed for specimens with 1% graphene, which was 20%, 23% and 25% lower than that of the dry ILSS strength for 1000, 2000 and 3000 h, respectively, as a result of the plasticization effect at the flax fibre/epoxy matrix interface from higher moisture absorption, which has been demonstrated at lower Tg values. This effect could be more pronounced by the agglomeration of graphene nanoparticles as the epoxy becomes more viscous af think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=39yo Middle Eastern female
|
file_name=biomedica_00626085.jpg caption=Intramuscular and extramuscular cisterns. Cisternography in a young woman who began experiencing pain in the upper extremity at the end of the first trimester. The ‘bunch of grapes’ pattern is seen around the clavicle (a), and an elongated cystic pattern is visible in and along the fascicles in the pectoralis major muscle (PM) (b). Appearance of the drainage vessel was faster at the PM aspect (not shown: continuous injection was terminated because of pain). MRI images (c–e) show continuity of the cisterns, with subclavicular cisterns showing continuity with those on the trapezius muscle and the PM. Symbols: white arrow, cisterns in the PM; dotted white arrow, cisterns in the trapezius muscle source=biomedica enhanced_caption=O: Intramuscular and extramuscular cisterns. Cisternography in a young woman who began experiencing pain in the upper extremity at the end of the first trimester. The ‘bunch of grapes’ pattern is seen around the clavicle (a), and an elongated cystic pattern is visible in and along the fascicles in the pectoralis major muscle (PM) (b). Appearance of the drainage vessel was faster at the PM aspect (not shown: continuous injection was terminated because of pain). MRI images (c–e) show continuity of the cisterns, with subclavicular cisterns showing continuity with those on the trapezius muscle and the PM. Symbols: white arrow, cisterns in the PM; dotted white arrow, cisterns in the trapezius muscle A: Clinical findings require correlation. P: Further evaluation recommended. think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=64yo Pacific Islander male
|
file_name=biomedica_00666457.jpg caption=We then tested whether PolII S2P binding and CRTC binding at Bx and Smr gene loci were mediated by GCN5, Tip60 or CRTC ( ="fig" "ncomms13471-f5">Fig. 5 ). In addition, H3K9Ac at ). In addition, H3K9Ac at Bx and H4K16Ac at Smr were examined, which were determined by ChIP-seq analysis ( ="fig" "ncomms13471-f3">Fig. 3e and and Supplementary Fig. 6a). We first confirmed that those are specific to LTM protocol by ChIP–quantitative PCR (qPCR): H3K9Ac and CRTC binding at Bx or H4K16Ac and CRTC binding at Smr were significantly enriched after spaced training, in comparison with those after massed training ( ="fig" "ncomms13471-f5">Fig. 5a,b ). At the ). At the Bx gene locus, CRTC binding after spaced training depended on GCN5 and Tip60, whereas PolII S2P and H3K9Ac after spaced training depended on expression of all three genes ( ="fig" "ncomms13471-f5">Fig. 5c ). This result is consistent with a model where GCN5 and Tip60 recruit CRTC to ). This result is consistent with a model where GCN5 an source=biomedica enhanced_caption=O: We then tested whether PolII S2P binding and CRTC binding at Bx and Smr gene loci were mediated by GCN5, Tip60 or CRTC ( ="fig" "ncomms13471-f5">Fig. 5 ). In addition, H3K9Ac at ). In addition, H3K9Ac at Bx and H4K16Ac at Smr were examined, which were determined by ChIP-seq analysis ( ="fig" "ncomms13471-f3">Fig. 3e and and Supplementary Fig. 6a). We first confirmed that those are specific to LTM protocol by ChIP–quantitative PCR (qPCR): H3K9Ac and CRTC binding at Bx or H4K16Ac and CRTC binding at Smr were significantly enriched after spaced training, in comparison with those after massed training ( ="fig" "ncomms13471-f5">Fig. 5a,b ). At the ). At the Bx gene locus, CRTC binding after spaced training depended on GCN5 and Tip60, whereas PolII S2P and H3K9Ac after spaced training depended on expression of all three genes ( ="fig" "ncomms13471-f5">Fig. 5c ). This result is consistent with a model where GCN5 and Tip60 recruit CRTC to ). This result is consistent with a model where GCN5 think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=64yo Pacific Islander male
|
file_name=biomedica_00216188.jpg caption=Several crystal structures of FabG are available in the PDB from E. coli (PDB ID 1I01) [41], A. baumannii (PDB ID 6T65) [98], and P. aeruginosa (PDB ID 4AG3) [94], for example. In solution, its active quaternary structure is homotetramer ( "pharmaceuticals-16-00425-g017" ="fig">Figure 17 A). The tertiary structure of each monomer shows a central twisted β-sheet composed of seven β-strands and surrounded by a total of eight α-helices on both sides. This structure is characteristic of Rossmann fold, which presents a cleft forming a nucleotide binding domain to receive the cofactor [A). The tertiary structure of each monomer shows a central twisted β-sheet composed of seven β-strands and surrounded by a total of eight α-helices on both sides. This structure is characteristic of Rossmann fold, which presents a cleft forming a nucleotide binding domain to receive the cofactor [45,47,99]. FabG possesses the Tyr-Lys-Ser catalytic triad ( "pharmaceuticals-16-00425-g017" ="fig">Figure 17 B) com source=biomedica enhanced_caption=O: Several crystal structures of FabG are available in the PDB from E. coli (PDB ID 1I01) [41], A. baumannii (PDB ID 6T65) [98], and P. aeruginosa (PDB ID 4AG3) [94], for example. In solution, its active quaternary structure is homotetramer ( "pharmaceuticals-16-00425-g017" ="fig">Figure 17 A). The tertiary structure of each monomer shows a central twisted β-sheet composed of seven β-strands and surrounded by a total of eight α-helices on both sides. This structure is characteristic of Rossmann fold, which presents a cleft forming a nucleotide binding domain to receive the cofactor [A). The tertiary structure of each monomer shows a central twisted β-sheet composed of seven β-strands and surrounded by a total of eight α-helices on both sides. This structure is characteristic of Rossmann fold, which presents a cleft forming a nucleotide binding domain to receive the cofactor [45,47,99]. FabG possesses the Tyr-Lys-Ser catalytic triad ( "pharmaceuticals-16-00425-g017" ="fig">Figure 17 B) think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=71yo Asian male
|
file_name=biomedica_00154044.jpg caption=To start the experiment, the pump was stopped and the cover of the P.O.P. trainer was removed. With a scalpel, a 2-3 cm thick slice of the liver was resected to create a deep tissue bleeding. After closure of the cover, the pump was activated again; the bleeding area was photodocumented ( ="fig" "SURGERY2011-518924.003">Figure 3 ). ). source=biomedica enhanced_caption=O: To start the experiment, the pump was stopped and the cover of the P.O.P. trainer was removed. With a scalpel, a 2-3 cm thick slice of the liver was resected to create a deep tissue bleeding. After closure of the cover, the pump was activated again; the bleeding area was photodocumented ( ="fig" "SURGERY2011-518924.003">Figure 3 ). ). A: Clinical findings require correlation. P: Further evaluation recommended. think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=58yo White female
|
file_name=biomedica_00511951.jpg caption=Compared with the lowest water intake group, the ORs for renal impairment gradually decreased as daily total water intake increased (low-moderate water intake, OR 0.58, 95% CI 0.52–0.65; high-moderate water intake, OR 0.38, 95% CI 0.34–0.43; highest water intake, OR 0.24, 95% CI 0.19–0.30) (Table 2). All demographic, socioeconomic, and medical history characteristics and sodium intake significantly affected the prevalence of renal impairment. The inverse relationship between total water intake and renal impairment remained significant after adjusting for the abovementioned risk factors according to models 1, 2 and 3. However, only the participants with low-moderate and high-moderate water intake had a significantly lower risk of renal impairment than those with the lowest water intake after additional adjustment for sodium intake according to model 4. Figure "10157_2020_1997_Fig2_HTML" ="fig">2 shows a restricted cubic spline curve of the ORs of total daily water intake for renal impai source=biomedica enhanced_caption=O: Compared with the lowest water intake group, the ORs for renal impairment gradually decreased as daily total water intake increased (low-moderate water intake, OR 0.58, 95% CI 0.52–0.65; high-moderate water intake, OR 0.38, 95% CI 0.34–0.43; highest water intake, OR 0.24, 95% CI 0.19–0.30) (Table 2). All demographic, socioeconomic, and medical history characteristics and sodium intake significantly affected the prevalence of renal impairment. The inverse relationship between total water intake and renal impairment remained significant after adjusting for the abovementioned risk factors according to models 1, 2 and 3. However, only the participants with low-moderate and high-moderate water intake had a significantly lower risk of renal impairment than those with the lowest water intake after additional adjustment for sodium intake according to model 4. Figure "10157_2020_1997_Fig2_HTML" ="fig">2 shows a restricted cubic spline curve of the ORs of total daily water intake for renal im think=<think>Visual findings present in image → Clinical correlation needed → ICD D49.9 assigned → Moderate uncertainty due to limited context</think> icd_code=D49.9 uncertainty=medium modality=multi-modal demographic=32yo Hispanic female
|
file_name=biomedica_00567281.jpg caption=Venn diagrams showing the overlap of the regulated proteins between Data Dependent Analysis (DDA) and Data Independent Analysis (DIA) of the ulcerative oral mucositis (ULC-OM) and non-oral mucositis (NON-OM) samples source=biomedica enhanced_caption=O: Venn diagrams showing the overlap of the regulated proteins between Data Dependent Analysis (DDA) and Data Independent Analysis (DIA) of the ulcerative oral mucositis (ULC-OM) and non-oral mucositis (NON-OM) samples A: Clinical findings require correlation. P: Further evaluation recommended. think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=71yo Asian male
|
file_name=biomedica_00358352.jpg caption=Figure "41598_2018_24030_Fig7_HTML" ="fig">7 shows the simulation results for the different designs of the slow-wave CPWs. SW0 refers to the inductive slow-wave CPW shown in Fig. shows the simulation results for the different designs of the slow-wave CPWs. SW0 refers to the inductive slow-wave CPW shown in Fig. "41598_2018_24030_Fig3_HTML" ="fig">3(b) with with w1 = 5 µm and w2 = 100 µm. The capacitive and inductive behavior of the slow-wave CPWs are depicted in Fig. "41598_2018_24030_Fig7_HTML" ="fig">7(a) . The capacitance is gradually improved up to a factor of four (from 0.2 to 0.8 nF/m) by the introduction of the capacitive T-rail elements in SW1 and their modifications in SW2 and SW3. The inductance is approximately constant for SW0, SW1 and SW2, but it increases from 1.05 to 1.67 µH/m for SW3 due to the changes in the ground slots and the modification of the signal strip. The impedance, Fig. . The capacitance is gradually improved up to a factor of four (from 0.2 to 0.8 nF/m) by source=biomedica enhanced_caption=O: Figure "41598_2018_24030_Fig7_HTML" ="fig">7 shows the simulation results for the different designs of the slow-wave CPWs. SW0 refers to the inductive slow-wave CPW shown in Fig. shows the simulation results for the different designs of the slow-wave CPWs. SW0 refers to the inductive slow-wave CPW shown in Fig. "41598_2018_24030_Fig3_HTML" ="fig">3(b) with with w1 = 5 µm and w2 = 100 µm. The capacitive and inductive behavior of the slow-wave CPWs are depicted in Fig. "41598_2018_24030_Fig7_HTML" ="fig">7(a) . The capacitance is gradually improved up to a factor of four (from 0.2 to 0.8 nF/m) by the introduction of the capacitive T-rail elements in SW1 and their modifications in SW2 and SW3. The inductance is approximately constant for SW0, SW1 and SW2, but it increases from 1.05 to 1.67 µH/m for SW3 due to the changes in the ground slots and the modification of the signal strip. The impedance, Fig. . The capacitance is gradually improved up to a factor of four (from 0.2 to 0.8 nF/m) think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=52yo Indigenous male
|
file_name=biomedica_00684425.jpg caption=To assess the correlation between FETUB and variables (FEV1%pred, RV%pred, RV/TLC% and CT emphysema%), Pearson correlation analysis was performed, and the corresponding scatter diagram is shown in ="fig" "srep30045-f4">Fig. 4 . To assess the correlation between FETUB and variables (grades of lung function and number of AE), Spearman correlation analysis was performed. The concentration of FETUB was negatively correlated with FEV1%pred (. To assess the correlation between FETUB and variables (grades of lung function and number of AE), Spearman correlation analysis was performed. The concentration of FETUB was negatively correlated with FEV1%pred (r = −0.446, p = 0.000), and positively correlated with RV%pred (r = 0.317, p = 0.004), RV/TLC% (r = 0.360, p = 0.004), CT emphysema% (r = 0.322, p = 0.008), grades of lung function (r = 0.456, p = 0.000) and number of AE (r = 0.326, p = 0.017). source=biomedica enhanced_caption=O: To assess the correlation between FETUB and variables (FEV1%pred, RV%pred, RV/TLC% and CT emphysema%), Pearson correlation analysis was performed, and the corresponding scatter diagram is shown in ="fig" "srep30045-f4">Fig. 4 . To assess the correlation between FETUB and variables (grades of lung function and number of AE), Spearman correlation analysis was performed. The concentration of FETUB was negatively correlated with FEV1%pred (. To assess the correlation between FETUB and variables (grades of lung function and number of AE), Spearman correlation analysis was performed. The concentration of FETUB was negatively correlated with FEV1%pred (r = −0.446, p = 0.000), and positively correlated with RV%pred (r = 0.317, p = 0.004), RV/TLC% (r = 0.360, p = 0.004), CT emphysema% (r = 0.322, p = 0.008), grades of lung function (r = 0.456, p = 0.000) and number of AE (r = 0.326, p = 0.017). A: Clinical findings require correlation. P: Further evaluation recommended. think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=28yo South Asian female
|
file_name=biomedica_00035970.jpg caption=For example, "sensors-21-06182-g001" ="fig">Figure 1 a shows a real-haze image provided by [a shows a real-haze image provided by [27]. This type of haze in "sensors-21-06182-g001" ="fig">Figure 1 a is different from what we have simulated, and degraded by multiple factors including the color attenuation, unbalanced light source and scattered light. Therefore, CNN-based estimation can not adaptively remove this real-haze as shown a is different from what we have simulated, and degraded by multiple factors including the color attenuation, unbalanced light source and scattered light. Therefore, CNN-based estimation can not adaptively remove this real-haze as shown "sensors-21-06182-g001" ="fig">Figure 1 b,c.b,c. source=biomedica enhanced_caption=O: For example, "sensors-21-06182-g001" ="fig">Figure 1 a shows a real-haze image provided by [a shows a real-haze image provided by [27]. This type of haze in "sensors-21-06182-g001" ="fig">Figure 1 a is different from what we have simulated, and degraded by multiple factors including the color attenuation, unbalanced light source and scattered light. Therefore, CNN-based estimation can not adaptively remove this real-haze as shown a is different from what we have simulated, and degraded by multiple factors including the color attenuation, unbalanced light source and scattered light. Therefore, CNN-based estimation can not adaptively remove this real-haze as shown "sensors-21-06182-g001" ="fig">Figure 1 b,c.b,c. A: Clinical findings require correlation. P: Further evaluation recommended. think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=58yo White female
|
file_name=biomedica_00087292.jpg caption=The first row in Fig. "12880_2021_608_Fig7_HTML" ="fig">7 shows an example of a patient with consolidations as a consequence of pneumonia after stem cell transplantation. In this case, both segmentations show high similarity according to a DSC of 0.979. shows an example of a patient with consolidations as a consequence of pneumonia after stem cell transplantation. In this case, both segmentations show high similarity according to a DSC of 0.979.Fig. 7Results of the substudy investigating generalizability are presented. The left column shows the anatomical image while on the right the lung labels of both segmentations can be depicted (yellow—manual, blue—automatic, green—consensus). Numbers are the DSC for the respective slice. First row: image of a patient with pneumonia after stem cell transplantation.The consolidations on both lungs are segmented correctly by the network. Second row: example of another patient with pneumonia. Consolidations are segmented correctly. Third row: differe source=biomedica enhanced_caption=O: The first row in Fig. "12880_2021_608_Fig7_HTML" ="fig">7 shows an example of a patient with consolidations as a consequence of pneumonia after stem cell transplantation. In this case, both segmentations show high similarity according to a DSC of 0.979. shows an example of a patient with consolidations as a consequence of pneumonia after stem cell transplantation. In this case, both segmentations show high similarity according to a DSC of 0.979.Fig. 7Results of the substudy investigating generalizability are presented. The left column shows the anatomical image while on the right the lung labels of both segmentations can be depicted (yellow—manual, blue—automatic, green—consensus). Numbers are the DSC for the respective slice. First row: image of a patient with pneumonia after stem cell transplantation.The consolidations on both lungs are segmented correctly by the network. Second row: example of another patient with pneumonia. Consolidations are segmented correctly. Third row: diff think=<think>Visual findings present in image → Clinical correlation needed → ICD J18.9 assigned → Moderate uncertainty due to limited context</think> icd_code=J18.9 uncertainty=medium modality=multi-modal demographic=67yo Asian female
|
file_name=biomedica_00742749.jpg caption="fnagi-13-717037-g001" ="fig">Figure 1 illustrates the workflow of image processing and data analysis conducted in this study. The pre-processing and denoising procedures were carried out using the functional connectivity toolbox CONN version 19.c. illustrates the workflow of image processing and data analysis conducted in this study. The pre-processing and denoising procedures were carried out using the functional connectivity toolbox CONN version 19.c.1 The pre-processing steps included functional image realignment and unwarping, slice-timing correction, outlier identification, direct segmentation, normalization, and spatial smoothing (Whitfield-Gabrieli and Nieto-Castanon, 2012). The first five and last four volumes of the rs-fMRI time series were discarded to avoid signal fluctuations. All rs-fMRI images were realigned to the first volume of the time series. The outliers were detected using the artifact detection tool (ART) implemented in CONN. To identify potential outliers with l source=biomedica enhanced_caption=O: "fnagi-13-717037-g001" ="fig">Figure 1 illustrates the workflow of image processing and data analysis conducted in this study. The pre-processing and denoising procedures were carried out using the functional connectivity toolbox CONN version 19.c. illustrates the workflow of image processing and data analysis conducted in this study. The pre-processing and denoising procedures were carried out using the functional connectivity toolbox CONN version 19.c.1 The pre-processing steps included functional image realignment and unwarping, slice-timing correction, outlier identification, direct segmentation, normalization, and spatial smoothing (Whitfield-Gabrieli and Nieto-Castanon, 2012). The first five and last four volumes of the rs-fMRI time series were discarded to avoid signal fluctuations. All rs-fMRI images were realigned to the first volume of the time series. The outliers were detected using the artifact detection tool (ART) implemented in CONN. To identify potential outliers wit think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=25yo White male
|
file_name=biomedica_00455592.jpg caption=The changes in the annexin V/7AAD patterns at different concentrations and exposure times of PHA-treated breast cancer cells were detected by flow cytometry ( ="fig" "antioxidants-10-00393-g003">Figure 3 A,C). PHA induced concentration- and time-dependent increases in apoptosis (annexin V (+)) (%) in the breast cancer cells (MCF7 and MDA-MB-231) (A,C). PHA induced concentration- and time-dependent increases in apoptosis (annexin V (+)) (%) in the breast cancer cells (MCF7 and MDA-MB-231) ( ="fig" "antioxidants-10-00393-g003">Figure 3 B,D). For Western blotting, the apoptosis expression was further examined at different time intervals. Apoptosis-signaling proteins such as c-PAPR, c-Cas 9, c-Cas 8, and c-Cas 3 were mildly increased at 12 h and dramatically increased at 24 h of PHA treatment in the breast cancer cells (B,D). For Western blotting, the apoptosis expression was further examined at different time intervals. Apoptosis-signaling proteins such as c-PAPR, c-Cas 9, c-Cas 8, and c- source=biomedica enhanced_caption=O: The changes in the annexin V/7AAD patterns at different concentrations and exposure times of PHA-treated breast cancer cells were detected by flow cytometry ( ="fig" "antioxidants-10-00393-g003">Figure 3 A,C). PHA induced concentration- and time-dependent increases in apoptosis (annexin V (+)) (%) in the breast cancer cells (MCF7 and MDA-MB-231) (A,C). PHA induced concentration- and time-dependent increases in apoptosis (annexin V (+)) (%) in the breast cancer cells (MCF7 and MDA-MB-231) ( ="fig" "antioxidants-10-00393-g003">Figure 3 B,D). For Western blotting, the apoptosis expression was further examined at different time intervals. Apoptosis-signaling proteins such as c-PAPR, c-Cas 9, c-Cas 8, and c-Cas 3 were mildly increased at 12 h and dramatically increased at 24 h of PHA treatment in the breast cancer cells (B,D). For Western blotting, the apoptosis expression was further examined at different time intervals. Apoptosis-signaling proteins such as c-PAPR, c-Cas 9, c-Cas 8, and think=<think>Visual findings present in image → Clinical correlation needed → ICD R69 assigned → Moderate uncertainty due to limited context</think> icd_code=R69 uncertainty=medium modality=multi-modal demographic=25yo White male
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.